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| 基于中西医临床病症特点分析腰椎间盘突出动物模型的构建与应用 |
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单凯欣1, 刘福宇1, 唐寅博1, 冯永岗1, 苗明三1,2, 方晓艳1,2
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1.河南中医药大学药学院, 郑州 450046;2.豫药全产业链研发河南省协同创新中心, 郑州 450046
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| 摘要: |
| 评估现有腰椎间盘突出症（LDH）动物模型的中西医临床吻合度。对比现有LDH动物模型与临床病症特点、影像学表现及中医辨证分型，分析现有模型的局限性。现有LDH动物模型与临床吻合度相对较高的是髓核移植模型，现有的模型未能充分考虑气候变化对LDH的影响，以及中医的辨证分型。未来的LDH动物模型研究应更加关注中医证型分类特点，建立多种动物模型。改进评价指标，增加气候因素及中医辨证指标。 |
| 关键词: 腰椎间盘突出症 临床病症 中西医 动物模型 |
| DOI：10.11656/j.issn.1672-1519.2025.08.18 |
| 分类号:R681.5 |
| 基金项目:国家自然科学基金项目（82074038）；河南省中医药科学研究专项（20-21ZY2156）；河南省科技研发计划联合基金项目（222301420091）；河南省留学人员科研择优资助项目（豫人社办函[2019]82号）。 |
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| Construction and application of animal models for lumbar disc herniation based on clinical characteristics in traditional Chinese and Western medicine |
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SHAN Kaixin1, LIU Fuyu1, TANG Yinbo1, FENG Yonggang1, MIAO Mingsan1,2, FANG Xiaoyan1,2
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1.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China;2.Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Genuine Medicine in Henan Province, Zhengzhou 450046, China
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| Abstract: |
| To evaluate the consistency between existing animal models of lumbar disc herniation（LDH） and clinical manifestations in both traditional Chinese and Western medicine. The existing LDH animal models were compared with clinical symptoms，imaging manifestations and traditional Chinese medicine syndrome differentiation，and the limitations of the existing models were analyzed. The nucleus pulposus transplantation model showed relatively high clinical consistency among existing LDH animal models. Current models fail to adequately consider the impact of climate factors on LDH progression or incorporate traditional Chinese medicine syndrome differentiation patterns. Future LDH animal model studies should emphasize traditional Chinese medicine syndrome classification characteristics by establishing diversified modeling approaches. Evaluation metrics should be improved by incorporating climate factors and traditional Chinese medicine syndrome differentiation indicators. |
| Key words: lumbar disc herniation clinical characteristics traditional Chinese and Western medicine animal models |
