心可舒片对心肌梗死后心力衰竭合并抑郁患者的临床疗效研究

The clinical efficacy of Xinkeshu Tablets in patients with heart failure and depression following myocardial infarction

关键词:  心肌梗死后心力衰竭  抑郁状态  心可舒片  临床研究

Key words:  heart failure after myocardial infarction  depressive state  Xinkeshu Tablet  clinical study

摘要:

[目的] 评价心可舒片治疗急性心肌梗死（AMI）后心力衰竭合并抑郁状态的临床疗效。[方法] 前瞻性纳入AMI后心力衰竭合并抑郁患者120例，根据心力衰竭患者是否使用心可舒片分为治疗组和对照组各60例。对照组给予西医常规药物治疗，治疗组在西医常规药物治疗的基础上给予心可舒片（每片0.31 g），每次4片，每日3次。两组疗程均为3个月。比较两组患者治疗前后左心室射血分数（LVEF）、明尼苏达心力衰竭生存质量量表（MLHFQ）、中医证候评分、汉密尔顿抑郁量表（HAMD）、抑郁自评量表（PHQ-9）等情况。[结果] 与治疗前比较，治疗3个月后两组LVEF显著提高，MLHFQ总分、中医证候评分、HAMD评分、PHQ-9评分均明显降低（P＜0.01）。与对照组比较，治疗3个月后治疗组的LVEF显著升高（P＜0.01），MLHFQ总分、中医证候评分、HAMD评分、PHQ-9评分明显降低（P＜0.05）。[结论] 在西医常规治疗基础上，应用心可舒片可改善心力衰竭合并抑郁患者胸痛胸闷、抑郁状况，从而提高生活质量。

Abstract:

[Objective] To evaluate the clinical efficacy of Xinkeshu Tablets in treating post-acute myocardial infarction（AMI） with heart failure and comorbid depressive symptoms. [Methods] A total of 120 patients with depression who developed heart failure after AMI were prospectively enrolled. Based on whether patients received Xinkeshu Tablets，they were divided into a treatment group（60 cases） and a control group（60 cases）. The control group received conventional Western medicine treatment，while the treatment group received Xinkeshu Tablets（0.31 g per tablet，4 tablets per dose，three times daily） in addition to conventional Western medicine treatment. Both groups were treated for a period of 3 months. Pre- and post-treatment comparisons included left ventricular ejection fraction（LVEF），Minnesota living with heart failure questionnaire（MLHFQ） scores，traditional Chinese medicine syndrome scores，Hamilton depression rating scale（HAMD），and patient health questionnaire-9（PHQ-9） scores. [Results] Compared with baseline，the treatment group showed greater improvement in LVEF（P＜0.01） and greater reductions in MLHFQ scores，traditional Chinese medicine syndrome scores，HAMD scores，and PHQ-9 scores（P＜0.01）. Compared with the control group，after 3 months of treatment，the treatment group exhibited greater improvement in LVEF（P＜0.01），and significant reductions in MLHFQ scores，traditional Chinese medicine syndrome scores，HAMD scores，and PHQ-9 scores（P＜0.05）. [Conclusion] On the foundation of conventional Western medical treatment，the use of Xinkeshu Tablets improves chest pain，chest tightness，and depressive symptoms in patients with heart failure complicated by depression，thereby enhancing quality of life.