当归拈痛汤加减联合羟苯磺酸钙片治疗糖尿病周围神经病变的临床疗效观察

The clinical efficacy of modified Danggui Niantong Decoction combined with calcium dobesilate tablets in treating diabetes peripheral neuropathy

关键词:  当归拈痛汤加减  羟苯磺酸钙片  糖尿病周围神经病变  临床疗效  炎性反应

Key words:  modified Danggui Niantong Decoction  calcium dobesilate tablet  diabetes peripheral neuropathy  clinical efficacy  inflammatory response

摘要:

[目的] 探究当归拈痛汤加减联合羟苯磺酸钙片治疗糖尿病周围神经病变（DPN）的临床疗效及对炎性反应的影响。[方法] 选取唐山市第三医院2023年1月至2024年6月收治的DPN患者92例，随机分为观察组、对照组，每组各46例。除了基础治疗外，给予对照组患者羟苯磺酸钙片治疗，观察组在对照组基础上联合当归拈痛汤加减进行治疗。比较两组患者疗效、治疗前后多伦多临床评分系统（TCSS）评分、感觉神经传导速度（SNCV）、运动神经传导速度（MNCV）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、血液流变学指标、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）。[结果] 观察组的疗效更优（P＜0.05）。治疗后两组患者TCSS评分、FPG和HbA1c、纤维蛋白原、全血低切黏度、血浆黏度、全血高切黏度、血清IL-6、TNF-α、CRP水平显著降低，正中神经和腓总神经SNCV、MNCV水平显著升高，且观察组更优（P＜0.05）。[结论] 当归拈痛汤加减联合羟苯磺酸钙片治疗DPN患者的效果显著，有利于降低患者血糖水平，改善神经传导速度和血液流变学指标，减轻炎症反应。

Abstract:

[Objective] To explore the clinical efficacy of modified Danggui Niantong Decoction combined with calcium dobesilate tablets in treating diabetes peripheral neuropathy（DPN） and its influence on inflammatory response. [Methods] From January 2023 to June 2024，92 patients with DPN who visited Tangshan Third Hospital were randomly divided into an observation group and a control group，with 46 patients in each group.In addition to basic treatment，the control group was treated with calcium dobesilate tablets，while the observation group was treated with modified Danggui Niantong Decoction in addition to the treatment received by the control group. To compare the efficacy，TCSS score，sensory nerve conduction velocity（SNCV），motor nerve conduction velocity（MNCV），fasting blood glucose（FPG），glycated haemoglobin（HbA1c），haematological rheological indexes，interleukin-6（IL-6），tumour necrosis factor-alpha（TNF-alpha），and C-reactive protein（CRP） between the two groups of patients before and after treatment. [Results] The therapeutic efficacy of the observation group was better（P＜0.05）. After treatment，the TCSS score，FPG，HbA1c，fibrinogen，whole blood low shear viscosity，plasma viscosity，whole blood high shear viscosity，serum IL-6，TNF-α，CRP levels in both groups were significantly decreased，while the SNCV and MNCV of the median and common peroneal nerves were prominently increased，and the observation group was better（P＜0.05）. [Conclusion] The combination of modified Danggui Niantong Decoction and calcium dobesilate tablets has a great effect on DPN patients，it is beneficial for reducing blood glucose levels，improving nerve conduction velocity and hemorheological indicators，and alleviating inflammatory response.