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| 雷公藤多苷片联合艾灸治疗类风湿关节炎的疗效及对患者血清炎性因子的影响 |
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李亮1, 赵品2, 张慧锦3, 柳晓青2, 王晓玉2, 郭静波4
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1.河北以岭医院风湿病二科, 石家庄 050091;2.正定256医院中医科, 石家庄 050800;3.中国人民解放军联勤保障部队第九八〇医院疾病预防控制科, 石家庄 050000;4.中国人民解放军联勤保障部队第九八〇医院中医科, 石家庄 050000
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| 摘要: |
| [目的] 探究雷公藤多苷片（TGT）联合艾灸治疗类风湿关节炎（RA）的疗效及对患者血清炎性因子的影响。[方法] 将142例RA患者按照随机数字表法分为TGT组和艾灸组，每组71例。TGT组采用TGT治疗，艾灸组在TGT组基础上联合艾灸治疗。比较两组临床疗效、临床症状、疼痛及功能评分、血清炎性因子[肿瘤坏死因子α（TNF-α）、超敏C反应蛋白（hs-CRP）、白细胞介素（IL）-6、IL-1β]、类风湿因子（RF）及不良反应发生率。[结果] 艾灸组总有效率为94.37%，显著高于TGT组的81.69%（P＜0.05）；治疗后，临床症状相关指标、视觉模拟量表（VAS）评分、健康评估问卷（HAQ）评分、TNF-α、RF、CRP、IL-6、IL-1β水平均下降，且艾灸组显著低于TGT组（P＜0.05）；TGT组、艾灸组不良反应总发生率比较差异无统计学意义（P＞0.05）。[结论] TGT联合艾灸治疗RA患者能够发挥良好的临床效果，缓解临床症状，减轻疼痛，改善关节功能，减少炎症反应，抑制病情发展，安全性高。 |
| 关键词: 雷公藤多苷片 艾灸 类风湿关节炎 临床疗效 疼痛评分 |
| DOI：10.11656/j.issn.1672-1519.2025.08.06 |
| 分类号:R593.22 |
| 基金项目:河北省中医药管理局科研计划项目（2021213）。 |
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| Therapeutic effect of Tripterygium Glycoside Tablets combined with moxibustion on rheumatoid arthritis and its impact on serum inflammatory factors in patients |
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LI Liang1, ZHAO Pin2, ZHANG Huijin3, LIU Xiaoqing2, WANG Xiaoyu2, GUO Jingbo4
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1.The Second Department of Rheumatology, Hebei Yiling Hospital, Shijiazhuang 050091, China;2.Department of Traditional Chinese Medicine, Zhengding 256 Hospital, Shijiazhuang 050800, China;3.Department of Disease Control and Prevention, The 980th Hospital of the Joint Logistics Support Force of PLA, Shijiazhuang 050000, China;4.Department of Traditional Chinese Medicine, The 980th Hospital of the Joint Logistics Support Force of PLA, Shijiazhuang 050000, China
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| Abstract: |
| [Objective] To evaluate the therapeutic effect of Tripterygium Glycoside Tablets（TGT） combined with moxibustion in the treatment of rheumatoid arthritis（RA） and its impact on serum inflammatory factors. [Methods] A total of 142 RA patients were randomly divided into the TGT group and the moxibustion group according to a random number table，with 71 cases in each group. The TGT group received TGT monotherapy，while the moxibustion group received additional moxibustion therapy. The following parameters were compared between the two groups：clinical efficacy，clinical symptoms，pain and functional scores，serum inflammatory factors [tumor necrosis factor-α（TNF-α），high-sensitivity C-reactive protein（hs-CRP），interleukin-6（IL-6），IL-1β]，rheumatoid factor（RF），and incidence of adverse reactions. [Results] The total effective rate was significantly higher in the moxibustion group（94.37%） than in the TGT group（81.69%，P＜0.05）. After treatment，all assessed parameters（clinical symptom-related indicators，Visual Analogue Scale score，Health Assessment Questionnaire score，TNF-α，RF，hs-CRP，IL-6，and IL-1β levels） showed significant reductions，with greater decreases in the moxibustion group（P＜0.05）. There was no statistical difference between TGT group and moxibustion group（P＞0.05）. [Conclusion] TGT combined with moxibustion demonstrates significant therapeutic effects for RA patients，including alleviation of clinical symptoms，pain relief，improved joint function，reduced inflammatory responses，and suppressed disease progression，with a favorable safety profile. |
| Key words: Tripterygium Glycoside Tablet moxibustion rheumatoid arthritis therapeutic efficacy pain score |
