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| 心脑一体：中医药现代研究的思路与方法 |
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江廷参1,2, 费庆林1,2, 管国强1,2, 肖光旭1,2, 樊官伟3,4, 朱彦1,2, 吕明1,2
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1.现代中药创制全国重点实验室, 天津中医药大学, 天津 301617;2.组分中药国家重点实验室, 天津中医药大学, 天津 301617;3.天津中医药大学第一附属医院, 天津 300381;4.国家中医针灸临床医学研究中心, 天津 300381
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| 摘要: |
| 心-脑疾病的相互影响严重增加了患者的致死率和经济负担。文章以中西医结合先驱张锡纯先生提出的“心脑共主神明”为纲本，通过整合传统和现代心脑关系的理论与实践，提出“心脑一体”理论现代研究的思路和方法。“心脑一体”理论主要包括两部分内容：心脑互作（脑心综合征和心脑综合征）和心脑同治，分别与中医心主神明和异病同治等理论相呼应。列举了如人工的智能、多组学和孟德尔随机化整合，类器官芯片，空间多组学整合，靶标垂钓等用现代科学技术解读“心脑一体”理论作用原理的前沿手段和方法。综上，文章首次系统整合中医理论与现代科学技术，提出“心脑一体”的研究框架，旨在促进“心脑一体”理论科学内涵的揭示，推进心-脑关系研究的快速发展，激发对中医“整体观”的思考和实践，促进中医药现代化发展。 |
| 关键词: 心脑一体 心脑共主神明 脑心综合征 心脑综合征 多组学 人工智能 |
| DOI：10.11656/j.issn.1672-1519.2025.09.17 |
| 分类号:R259.743 |
| 基金项目:天津市教委科研计划项目（2022KJ148）；天津市科技创新基地建设（24ZYJDSS00320）；国家自然科学基金青年项目（82104431），国家自然科学基金重点项目（82430121）；现代中药新质生产力科技创新工程专项（24ZXZKSY00030）；京津冀基础研究合作专项（23JCZXJC00380）；贵州省科技计划项目（黔科合支撑[2023]一般100）；组分中药国家重点实验室青苗基金项目（CBCM2023205）。 |
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| Heart-brain integration: The ideas and methods of modern research on traditional Chinese medicine |
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JIANG Tingcan1,2, FEI Qinglin1,2, GUAN Guoqiang1,2, XIAO Guangxu1,2, FAN Guanwei3,4, ZHU Yan1,2, LYU Ming1,2
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1.National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;3.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;4.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
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| Abstract: |
| The two-way feedback of heart-brain disease based on the “heart-brain axis” seriously increases the mortality and economic burden of patients. We put forward the ideas and methods of the theory of “heart-brain integrity” by integrating traditional and modern theory and practice of the relationship between heart and brain based on the theory of “both heart and brain are in charge of mental activity” proposed by ZHANG Xichun. The theory of “heart-brain integration” mainly includes two parts：heart-brain interaction（brain-heart syndrome and heart-brain syndrome） and heart-brain co-treatment. They are corresponding to the traditional Chinese medicine theory of the heart controls mental activities and the co-treatment of heart and brain. The cutting-edge means and methods to interpret the principle of “heart-brain integration” theory with modern science and technology are illustrated，such as integration of artificial intelligence，multi-omics and Mendelian randomization，organoid chip，integration of spatial metabolome and spatial transcriptome，and target fishing. In summary，we are aiming at promoting to reveal the scientific connotation of “heart-brain integration” theory，facilitating the rapid research development between heart and brain relationship，stimulating the thinking and practice of the “holistic view” of traditional Chinese medicine，and contributing the modernization of traditional Chinese medicine. |
| Key words: heart-brain integration heart and brain both govern the spirit brain-heart syndrome heart-brain syndrome multi-omics artificial intelligence |
