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| 基于国医大师张大宁教授肾虚血瘀论和补肾活血法论治常染色体显性遗传性多囊肾病 |
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丁盛1, 冯路达2, 陈澍1, 董少宁3, 邓媛媛1, 贺鹏飞4, 王宇琦1, 张勉之3,5,6
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1.北京中医药大学研究生院, 北京 100029;2.首都医科大学附属宣武医院, 北京 100053;3.天津市中医药研究院附属医院, 天津 300120;4.首都医科大学附属北京中医医院, 北京 100010;5.北京中医药大学东方医院, 北京 100078;6.天津市南开医院, 天津 300100
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| 摘要: |
| 常染色体显性遗传性多囊肾病（ADPKD）是一种进行性发展且无法治愈的遗传性肾脏疾病，是导致终末期肾脏病（ESRD）的常见原因。“肾虚血瘀论”与“补肾活血法”由国医大师张大宁教授首创，现已成为中医药治疗慢性肾脏病的一项大法。文章立足于该学术思想，将常染色体显性遗传性多囊肾病核心病因概括为“先天不足，后天损伤”；认为“虚、瘀、毒”的动态发展是恶化的关键环节；疾病进展规律为“初病脾肾，中及肝肾，末期戕害多脏腑，肾虚血瘀贯穿始终”。因此，基于肾虚血瘀论和补肾活血法论治常染色体显性遗传性多囊肾病，为临床诊疗提供了新的参考。 |
| 关键词: 常染色体显性多囊肾病 肾虚血瘀论 补肾活血法 张大宁 |
| DOI：10.11656/j.issn.1672-1519.2026.03.01 |
| 分类号:R692 |
| 基金项目:中央高水平中医医院临床科研业务费（DFRCZY- 2024ARC-003）；中国中医科学院科技创新工程项目——学部委员张大宁教授治疗肾脏病的多维度传承（C12022E024XB）；张勉之天津市名中医传承工作室（402164）；中央高校基本科研业务费专项资金（2024-JYB-XJSJJ025）；天津市中医药研究院附属医院研究项目（2022008）；天津市公共卫生科技重大专项（24ZXGZSY00160）。 |
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| The novel treatment strategy for ADPKD based on the theory of kidney deficiency and blood stasis and the therapy of tonifying kidney and promoting blood circulation proposed by national traditional Chinese medicine Master ZHANG Daning |
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DING Sheng1, FENG Luda2, CHEN Shu1, DONG Shaoning3, DENG Yuanyuan1, HE Pengfei4, WANG Yuqi1, ZHANG Mianzhi3,5,6
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1.Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China;2.Xuanwu Hospital, Capital Medical University, Beijing 100053, China;3.Tianjin Academy of Tradtional Chinese Medicine Affiliated Hospital, Tianjin 300120, China;4.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;5.Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;6.Tianjin Nankai Hospital, Tianjin 300100, China
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| Abstract: |
| Autosomal dominant polycystic kidney disease（ADPKD） is a progressive and incurable hereditary renal disease，which is a common cause of end stage renal disease（ESRD）. “The theory of kidney deficiency and blood stasis” and “the therapy of tonifying kidney and promoting blood circulation” were initiated by national traditional Chinese medicine Master ZHANG Daning，and have now become a common therapy in the treatment of chronic kidney disease with traditional Chinese medicine. Based on “the theory of kidney deficiency and blood stasis” and “the therapy of tonifying kidney and promoting blood circulation”，we summarize the core etiology of ADPKD as “congenital deficiency and acquired injury”. The dynamic development of “deficiency，stasis and toxin” is the key link of the deterioration of the disease. The progression of the disease is as follows：“ADPKD initially affects the spleen and kidney，then involves the liver and kidney in the middle stage，and in the end stage，it often damages multiple viscera. Throughout the entire process，kidney deficiency and blood stasis are consistently present.” Therefore，based on “the theory of kidney deficiency and blood stasis” and “the therapy of tonifying kidney and promoting blood circulation”，the treatment of ADPKD provides a novel reference for clinical diagnosis and therapy. |
| Key words: autosomal dominant polycystic kidney disease the theory of kidney deficiency and blood stasis the therapy of tonifying kidney and promoting blood circulation ZHANG Daning |
