| 摘要: |
| 轻度认知障碍（MCI）是介于正常衰老与阿尔茨海默病（AD）之间的过渡状态，针刺及联合治疗主要通过减少β-淀粉样蛋白（Aβ）沉积、抑制Tau蛋白的过度磷酸化、抑制神经炎症、抑制氧化应激反应等作用机制治疗MCI。环磷酸腺苷（cAMP）-蛋白激酶A（PKA）-cAMP响应性元件结合蛋白（CREB）通路具有多环节、多途径、多靶点调节MCI的特点，与针刺及联合治疗改善神经退行性改变密切相关。文章基于cAMP/PKA/CREB信号通路对针刺及联合治疗防治MCI的相关机制进行综述，以期为今后针对MCI的基础及临床研究提供思路。 |
| 关键词: 轻度认知功能障碍 cAMP/PKA/CREB信号通路 针灸 康复 阿尔茨海默病 |
| DOI：10.11656/j.issn.1672-1519.2026.03.16 |
| 分类号:R245 |
| 基金项目:国家自然科学基金项目（82174509）。 |
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| Research progress on the mechanism of acupuncture and combined treatment regulating cAMP-PKA-CREB pathway to improve mild cognitive impairment |
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WANG Zhaoyu1, JING Jiayi2, ZHAO Guodong1, ZHANG Miao3
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1.Heilongjiang University of Chinese Medicine, Harbin 150040, China;2.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China;3.NO. 10 Acupuncture and Moxibustion Department, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
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| Abstract: |
| Mild cognitive impairment（MCI） is a transitional state between normal aging and Alzheimer’s disease（AD）. Acupuncture and combined treatment mainly treat MCI by reducing amyloid β-protein（Aβ） deposition，inhibiting hyperphosphorylation of Tau protein，inhibiting neuroinflammation and inhibiting oxidative stress. The cyclic adenosine monophosphate（cAMP）-protein kinase A（PKA）-cAMP responsive element binding protein（CREB） pathway has the characteristics of multi-link，multi-pathway and multi-target regulation of MCI，which is closely related to the improvement of neurodegenerative changes by acupuncture and combined treatment. Based on the cAMP/PKA/CREB signaling pathway，this paper reviews the related mechanisms of acupuncture and combined therapy in the prevention and treatment of MCI，in order to provide ideas for basic and clinical research on MCI in the future. |
| Key words: mild cognitive impairment cAMP/PKA/CREB signaling pathway acupuncture and moxibustion rehabilitation Alzheimer’s disease |
