基于“扶正祛邪”治则探讨贞芪扶正制剂治疗癌症的研究进展

Research progress of Zhenqi Fuzheng Preparations in cancer treatment based on the principle of “Fuzheng Quxie”

关键词:  扶正祛邪  癌症  贞芪扶正制剂  中西医结合治疗

Key words:  Fuzheng Quxie  cancer  Zhenqi Fuzheng Preparations  integrative Chinese-Western medicine treatment

摘要:

作为重大的公共卫生问题，癌症对公众健康构成了严重威胁，现行的手术、放疗、化疗和靶向治疗等常规治疗方案在疗效与安全性方面仍存在一定局限。现有研究表明，中医药作为辅助治疗手段，在规范治疗基础上有助于提升疗效并减少治疗相关不良反应。贞芪扶正制剂作为肿瘤患者中广泛应用的扶正类中成药，具有增强正气、改善免疫功能、调节肠道菌群、减轻化疗不良反应等多重作用。基于“扶正祛邪”治则，结合中医病机与现代研究成果，系统梳理了贞芪扶正制剂用于癌症治疗的中医理论基础、其抗肿瘤的有效成分及药理作用、临床研究进展，旨在为优化肿瘤防治策略提供理论依据与实践参考。

Abstract:

Cancer is a major public health problem that poses a serious threat to public health. Current standard treatments，including surgery，radiotherapy，chemotherapy and targeted therapies，remain limited in terms of efficacy and safety. Existing studies suggest that traditional Chinese medicine，as an adjuvant therapy，can enhance treatment efficacy and reduce therapy-related adverse events when combined with standard care. Zhenqi Fuzheng Granule（ZQFZ），a widely used traditional Chinese medicine formulation among cancer patients，exerts multiple functions including strengthening vital qi，enhancing immune function，modulating the gut microbiota，and alleviating the side effects of chemotherapy. Based on the traditional Chinese medicine principle of “strengthening the body’s resistance and eliminating pathogenic factors”，this paper systematically reviews the traditional Chinese medicine theoretical foundation of ZQFZ in cancer treatment，its active anti-tumor components and pharmacological effects，as well as current clinical research progress，with the aim of providing theoretical support and practical reference for optimizing integrated traditional Chinese medicine and Western medicine strategies in cancer therapy.