针刺治疗更年期综合征的实验研究

Experimental Research on Climacteric Syndrome Treated by Acupuncture

关键词:  更年期综合征  电针  生殖内分泌免疫网络

Key words:  Climacteric syndrome  Electroacupuncture  Immunological network of reproductive endocrine

摘要:

目的: 探索针刺治疗更年期综合征的作用机制。方法: 选用11～15月龄雌性SD大鼠为自然更年期模型,以电针足三里、三阴交、关元及太冲穴为针刺处方,在电针治疗30天后测定血清雌二醇(E₂)、促性腺激素(FSH、LH)及白细胞介素-2(IL-2),并做卵巢和肾上腺的组织形态学观察。结果: 电针可使针刺组大鼠下降的E₂水平显著回升(P<0.05),异常升高的FSH、LH明显下降(P<0.01～0.05),并明显升高血清IL-2水平(P<0.05),提高更年期大鼠的细胞免疫功能。电针还可增加肾上腺重量,改善肾上腺皮质形态。结论: 电针可以调节更年期大鼠生殖内分泌,提高免疫力,对更年期衰退的生殖内分泌免疫网络起综合性调节作用。

Abstract:

Objective: To investigate the therapeutic mechanism of climacteric syndrome treated with electroacupuncture.Methods: We selected "Zusanli","Sanyinjiao","Guanyuan","Taichong" as the prescription,used SD female rats of 11～15 months old as the natural cli-mac terum models.After 30 days,we observed the change of serum E₂ level,sexual stimulating hormone(FSH and LH),and serum IL-2 of them.We also made the morphological observation of their ovary and suprarenal.Results: The research in dicated that electroacupunc-ture can evidently decrease the level of sexual stimulating hormone and elevate the level of serum E₂ level of model rats(P<0.01～0.05);it also can increase the content of serum IL-2 of model rats(P<0.05).Conclusion: Eletroacupuncture can regulate reproduction en-docrine;it also can improve immunity of climacterum rats.It may produce a syn thetic effect on immune network reproductive endocrine of them,hav ing the feature of totally regulating through multiway.