中药清解灵对肝脏保护作用的实验研究

Experimental Study of Qingjieling on the Protective Effects of the Liver

关键词:  急性重症胆管炎  中药  肝功生化指标

Key words:  Acute cholangitis severe type(ACST)  Chinese herbal medicine  Biochemi cal imdex of hepatic function

摘要:

目的: 探讨中药清解灵对急性重症胆管炎(ACST)大鼠肝损害的保护作用.方法: 制造急性重症胆管炎大鼠模型,通过测定血清中ALT、AST、ALP、r-GT、TBA、PaIb活性或浓度变化,观察中药清解灵配合胆管减压的治疗作用.结果: 急性重症胆管炎大鼠肝脏受损严重.表现为血清ALT、AST、ALP、r-GT、TBA较正常组明显升高(P<0.05或P<0.01或P<0.001),PaIb较正常组明显降低(P<0.01).治疗后,尽管ALT、AST和ALP仍高于正常组(P<0.001或P<0.01或P<0.05),但与造模组相比已显著降低(P<0.05或P<0.001).结论: 中药清解灵对肝脏有保护作用.

Abstract:

Objective: To explore the protective effects of Qingjielin on the hepatic damage of rats with acute cholangitis severe type(ACST).Methods: The rat model with ACST was made,The activityconcentration of ALT,AST,ALP,r-GT,TBA,PaIb in serum were tested and then the therapeutic effects of Qingjielin combined with of choledochostomy were observed.Results: ACST can do great damage to the rat liver.The ALT,AST,ALP,r-GT,TBA contents in serum of the model group were greatly raised(P<0.05,or P<0.01,or P<0.001),and the content of PaIb was remarkably reduced as compared with those of the normal control group.Although the contents of ALT,AST,ALP in the herb-plus-operation group were still higher than that inthe normal control groip,they reduced remarkably when compared with the model group.Conclusion: Qingjieling plays a role in protecting the liver from ACST.