| 摘要: |
| 目的: 研究糖复康对糖尿病大鼠肾皮质转化生长因子β1（TGFβ1）表达的影响。方法: 以链脲佐菌素尾静脉注入法制作糖尿病大鼠模型。将成模大鼠分为模型组、糖复康低剂量组、糖复康高剂量组、苯那普利组,并设正常对照组。检测指标有尿蛋白排泄率（UTP）、肾皮质蛋白质非酶糖化终产物（AGEs）、TGFβ1、Ⅳ型胶原蛋白（Ⅳ-C）、纤维连接蛋白（FN）。结果: 糖复康可下调UTP,与苯那普利作用相似,与模型组比较差异显著（P<0.01）;糖复康下调糖尿病大鼠肾皮质AGEs表达而苯那普利无此作用;糖复康也可降低肾皮质TGFβ1表达,减轻Ⅳ-C、FN的聚积。结论: 糖复康下调TGFβ1可能是其治疗糖尿病的机制之一。 |
| 关键词: 糖复康 转化生长因子β1（TGFβ1） 表达 |
| DOI：10.11656/j.issn.1673-9043.2002.03.34 |
| 分类号: |
| 基金项目:天津市自然基金资助课题(973609011) |
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| Influence of Tangfukang on Expression of Renocortical Transforming and Growth Factor β1(TGFβ1) in Diabetic Bat |
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Guo Hui,Zhang Bolin
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The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193
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| Abstract: |
| vein.There were 5 group:nolmal group,model group,low dose of Tangfukang group,high dose of Tangfukang group,benazepril group,The indexes were AGE2,TGFβ1,FN,IV-C,UTP.Results:Tangfukang could decrease UTP and had a same result with benazepril.There was an obvious difference between Tangfukang group and model group(P<0.01).Tangfukang could decrease AGE2 expression,but benazepril couldn't.It also could lower TGFβ1expression and decrease the accumulation of IV-C and FN.Conclusion: The influence of Tangfukang on renocortical TGFβ1 expression in diabetic rats may be one of the mechanisms of action on DM. |
| Key words: Tangfukang TGFβ1 expression |
