| 摘要: |
| [目的]以内皮细胞(EC)为研究对象,观察救心胶囊对缺氧损伤内皮细胞黏附分子释放的影响。[方法]运用免疫细胞化学技术,通过进行内皮细胞培养,观察内皮细胞缺氧损伤后,黏附分子(VCAM-1、ICAM-1)在细胞浆的表达情况。[结果]缺氧损伤使VCAM-1、ICAM-1表达显著升高。救心胶囊组,VCAM-1、ICAM-1表达显著降低。[结论]救心胶囊能显著降低黏附分子表达,保护内皮细胞免受炎症介质损伤。 |
| 关键词: 救心胶囊 黏附分子 内皮细胞 缺氧 |
| DOI：10.11656/j.issn.1673-9043.2004.03.08 |
| 分类号: |
| 基金项目:*天津市卫生局课题(02042) |
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| The influence of Jiuxin capsule on the expression of adhesion molecule from injured endothelium cell by hypoxia |
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LI Chun-shen, CEHN jing, FAN Ying-chang
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Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] The mechanism of Jiuxin capsule on coronary heart disease (CHD) through observing the influence of Jiuxin capsule on the expression of adhesion molecule from injured endothelium cell by hypoxia.[Methods] Through cultivating endothelium cell in vitro,the expression of adhesion molecule (VCAM-1,ICAM-1) in cytoplasm was observed by immunochemistry in hypoxia injured endothelium cell.[Result] The expression of adhesion molecule increased markedly after endothelium cell was injured by hypoxia,and Jiuxin capsule coul inhibit.[Conclusion] Jiuxin capsule can marked1y decrease the expression of adhesion molecule of endothelium cell and protect the endothelium cell against injured by inflammation mediater. |
| Key words: Jiuxin capsule adhesion molecule endothelium cell hypoxia |
