| 摘要: |
| [目的]观察中药心复康对心肌梗死大鼠促血管新生的影响,探讨中药对心室重塑的保护作用。[方法]采用冠状动脉结扎法制作心肌梗死模型,术后随机分为假手术组、模型组、中药高剂量组和中剂量组,每组12只。中药高剂量[81g/(kg·d)]和中剂量组[40.5g/(kg·d)]给予中药心复康水煎剂灌胃,假手术组和模型组每天等量生理盐水灌胃。28d后处死动物,病理切片观察心脏微观结构改变;免疫组化方法计数心肌梗死灶、边缘区新生血管数。[结果]中药组大鼠心肌梗死面积明显缩小,梗死灶及周围组织中微血管密度、明显高于模型组及假手术对照组。[结论]在大鼠心肌梗死模型中,中药组能够有效促进微血管新生,减少胶原纤维的生成,减轻心肌梗死后心室重塑。 |
| 关键词: 心复康 心肌梗死 血管新生 |
| DOI：10.11656/j.issn.1673-9043.2007.03.12 |
| 分类号: |
| 基金项目:*天津市卫生局科研课题资助项目(200507) |
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| Effect of XinFuKang on left ventricular remodeling and enhancing angiogenesis after myocardial infarction in rats |
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MA Wen-li, GUO Ma-juan, HUA Sheng-yu
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Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the impact of XinFuKang on left ventricular remodeling (LVRM) and angiogenesis after myocardial infarction (MI) in rats.[Methods] The model of myocardial infarction was induced by ligating the descending left coronary artery in male rats.Twentyfour hours later,48 survied rats with AMI were randomly divided into myocardial infarction control group,sham-operated group,Xinkukang middle dose group and Xinfukang high dose group.After four weeks of therapy,cardia tissue section were observed by immunohistochemistry.[Results] Compared to sham operated,Xinfukang high dose group can enhance angiogenesis and inhibit collagen fibers increased and disordered.[Conclusion] Xinfukang can prevent LVRM after MI in rats,prohibit collagen fibers hyperplasia and enhance angiogenesis. |
| Key words: XinFuKan myocardial infarctio angiogenesis |
