| 摘要: |
| [目的]研究丹酚酸B(SalB)、三七总皂苷(PNS)对心肌梗死大鼠左室结构和功能的影响,探讨中药组分配伍的作用。[方法]结扎冠脉左前降支复制大鼠心肌梗死模型,假手术组作对照,连续灌胃给药7d。用彩色超声心动仪观察心脏左室结构和功能变化。[结果]SalB、PNS以及配伍组可以不同程度地降低左室收缩末期内径(LVDs)、左室收缩末期容积(LVESV),升高左室射血分数(EF)、左室短轴缩短率(FS),配伍组有优于其他中药组的趋势。[结论]SalB、PNS配伍可以有效改善心肌梗死大鼠的左室结构和功能。 |
| 关键词: 丹酚酸B 三七总皂苷 配伍 左心室 心肌梗死 |
| DOI：10.11656/j.issn.1673-9043.2007.03.13 |
| 分类号: |
| 基金项目:*国家重点基础研究发展计划973课题资助项目(2005CB523404) |
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| Effect of the combination of Sal B and PNS on left ventricular construction and function of rats with myocardial infarction |
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ZHANG Meng,GAO Xiu-mei,WANG Yi
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Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] In order to elucidate the scientific connotation of compatibility in traditional Chinese medicine (TCM) formulas,we observed the effects of Salvianolic acid B (Sal B) and panax notoginseng saponins (PNS) used alone and in combination on rats with acute myocardial infarction.[Methods] To produce myocardial infarction in anaesthetized rats by occluding the left descending coronary artery.Sham-operated rats served as controls.To assayed the construction and function of left ventricular by using echocardiography.[Results] Sal B,PNS and the combination of Sal B and PNS can decrease LVDs,LVESV and increase EF and FS. There was a trend that the effects of the combination of Sal B and PNS were better than others.[Conclusion] The combination of Sal B and PNS can improve the heart function effectively. |
| Key words: Salvianolic acid B panax notoginseng saponins compatibility left ventricular myocardial infarction |
