| 摘要: |
| [目的]观察糖脂清对实验性2型糖尿病大鼠糖代谢和脂代谢紊乱的影响。[方法]采用Wistar大鼠喂饲高脂饲料8周后,一次性腹腔注射2%链脲佐菌素30mg/kg的方法复制2型糖尿病动物模型。按糖脂清用药剂量为3.2,1.6,0.8g生药/kg体质量灌胃给药,以血脂康(0.25g/kg体质量)及二甲双胍(0.25g/kg体质量)作为阳性对照药,给药30d后检测空腹血糖、血脂、胰岛素、糖化血红蛋白水平。[结果]糖脂清能显著降低实验性2型糖尿病大鼠的空腹血糖水平,降低血脂含量,降低胰岛素,糖化血红蛋白水平,升高胰岛素敏感性,与模型组比较有显著性差异(P<0.05,P<0.01)。[结论]糖脂清对实验性2型糖尿病大鼠模型有降低血糖,调节血脂,改善糖脂代谢紊乱的作用。 |
| 关键词: 2型糖尿病 糖脂清 糖代谢 脂代谢 |
| DOI：10.11656/j.issn.1673-9043.2010.02.09 |
| 分类号: |
| 基金项目:* 科技部国际合作项目资助(2009DFA31070);国家科技重大专项“重大新药创制”项目资助(2009ZX09102-128) |
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| Effect of tangzhiqing on glycolipid metabolism in rats with experimental type 2 diabetes |
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LI Yu-hong, ZHANG De-qin, Wang Xi
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The TCM Research Institute in Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin China 300193
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| Abstract: |
| [Objective] To observe the effects of Tangzhiqing (TZQ) on glycolipid metabolism in experimental type 2 diabetic rats.[Methods] Wistar rats were fed with high fat diet for 8weeks and then were injected intraperitoneally with streptozotocin (STZ,30 mg/kg) to induce experimental type 2 diabetes.The model rats were administrated with medicine at the dose of 6,3,1.5g of crude drug/kg for 30 days, using metformin hydrochloride tablets (0.25 g/kg),Xuezhikang (0.25 g/kg) as the control.At the end,the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin were measured.[Results] Compared with the model group,TZQ could obviously decrease the levels of the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin (P<0.05,P<0.01),and increase insulin-sensitivity index.[Conclusion] TZQ can effectively regulate glycolipid metabolism disorder. |
| Key words: type 2 diabetes mellitus Tangzhiqing glucose metabolism lipid metabolism |
