姜黄素、小檗碱及其配伍对db/db小鼠糖脂代谢的影响*

Effect of curcumin,berberine and its compatibility on glucose and lipid metabolism in db/db mice

关键词:  姜黄素  小檗碱  配伍  db/db小鼠  糖脂代谢

Key words:  curcumin  berberine  compatibility  db/db mice  glucose and lipid metabolism

摘要:

[目的]观察姜黄素、小檗碱分别及其配伍对db/db小鼠糖脂代谢的影响,为中药配伍合理性提供实验依据。[方法]db/db小鼠口服给予姜黄素和小檗碱,28d后,观察分别及其配伍对小鼠体质量、脏器系数、血清基础血糖、糖耐量曲线、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇的影响。[结果]各给药组均可显著降低db/db小鼠的肝脏系数(P<0.05);姜黄素低剂量(19.5mg/kg)小檗碱高剂量(144mg/kg)配伍组和姜黄素高剂量(39mg/kg)小檗碱高剂量(144mg/kg)配伍组可显著降低db/db小鼠基础血糖(P<0.05);姜黄素低剂量(19.5mg/kg)小檗碱高剂量(144mg/kg)配伍组和姜黄素高剂量(39mg/kg)小檗碱高剂量(144mg/kg)配伍组可显著调节改善db/db小鼠糖耐量曲线(P<0.05);姜黄素低剂量(19.5mg/kg)组、姜黄素高剂量(39mg/kg)小檗碱低剂量(72mg/kg)配伍组和姜黄素低剂量(19.5mg/kg)小檗碱高剂量(144mg/kg)配伍组可明显降低db/db小鼠甘油三酯的水平(P<0.05)。[结论]将小檗碱和姜黄素进行配伍组合,其改善db/db小鼠的糖脂代谢紊乱的作用优于单独给药组,且姜黄素低剂量(19.5mg/kg)小檗碱高剂量(144mg/kg)配伍组综合表现出更为明显的疗效。

Abstract:

[Objection] To observe the effect of curcumin,berberine and its compatibility on glucose and lipid metabolism in db/db mice,and provide experimental basis for the rationality of compatibility.[Methods] Curcumin,berberine and combined application of both were orally administrated to the db/ db mice for 28 days,to observe the effect of body weight,organ coefficient,based glucose,glucose tolerance curve,CHO,TG,HDL-C and LDL-C in db/db mice.[Results] All treated groups can significantly reduce the db/db mice liver coefficient (P<0.05) ,curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group and curcumin high-dose (39 mg/kg) berberine high-dose (144 mg/kg) compatibility group can significantly reduce the db/db mice serum-based glucose (P<0.05) ,curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group and curcumin high-dose (39 mg/kg) berberine high-dose (144 mg/kg1) compatibility group can significantly improve and regulate the glucose tolerance curve of db/db mice (P<0.05) ,curcumin low-dose (19.5 mg/kg) group,curcumin high-dose (39 mg/kg) berberine low-dose (72 mg/kg) compatibility group and curcumin low-dose (19.5 mg/ kg) berberine high-dose (144 mg/kg) compatibility group can significantly reduce the level of the TG in db/db mice (P<0.05).[Conclusion] The compatibility of curcumin with berberine can significantly improve the glucose and lipids metabolism disorders of the db/db mice to a certain extent,and its effect better than the separate administration group,and curcumin low-dose (19.5 mg/kg) berberine high-dose (144 mg/kg) compatibility group integrated to show a more significant effect.