| 摘要: |
| [目的]观察芍药苷的抗抑郁作用及可能的作用机制。[方法]利用小鼠强迫游泳实验,观察芍药苷对小鼠不动时间的影响。采用高效液相色谱法(HPLC)法检测小鼠脑组织中单胺神经递质含量变化。[结果]芍药苷(100、200mg/kg组)可显著缩短小鼠强迫游泳的不动时间,并且芍药苷(200mg/kg组)可升高脑组织中去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量。[结论]芍药苷具有一定的抗抑郁作用,其机制可能与增加脑内单胺递质含量有关。 |
| 关键词: 芍药苷 抗抑郁药 单胺递质 |
| DOI：10.11656/j.issn.1673-9043.2012.02.08 |
| 分类号: |
| 基金项目:* 天津市高等学校科技发展基金项目(20080207) |
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| Effect of paeoniflorin on cerebral neurotrnsmitter in forced-swimming mice |
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CUI Guang-zhi1, JIN Shu-mei2
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1.Tianjin University of TCM, Tianjin 300193, China;2.Tianjin Hospital of Huanhu, Tianjin 300060, China
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| Abstract: |
| [Objective] To investigate the antidepressant effects and the possible mechanism of paeoniflorin.[Methods] The antidepressant effects was evaluated by forced-swimming tests (FST). The content of monoamine neurotransmitters was measured by the HPLC assay.[Results] Paeoniflorin (100 and 200 mg/kg) could significantly reduce the duration of immobility in FST, and Paeoniflorin (200 mg/kg) can significantly increase the contents of Norepinephrine (NE), dopaimine (DA) and 5-hydroxytryptamine (5-HT) in mouse brain.[Conclusion] Paeoniflorin has remarkable antidepressant effect, and its mechanism may be involved in monoaminergic nervous system. |
| Key words: paeoniflorin antidepressant monoamine transmitters |
