“从肾论治”小儿癫痫的临床研究*

Clinical study on treatment from the kidney with pediatric epilepsy

关键词:  益肾填精法  小儿癫痫  认知损害

Key words:  method of tonifying kidney and essence replenishment  pediatric epilepsy  cognitive impairment

摘要:

[目的]评价益肾填精法治疗小儿癫痫强直-阵挛性发作的有效性与安全性。[方法]以强直-阵挛性发作患儿为研究对象,随机分为3组,分别予茸菖胶囊、抗痫胶囊、卡马西平治疗1年,观察患儿癫痫发作频率、持续时间、脑电图、中医证候、认知功能的测定及肝肾功能等安全性指标,进行疗效评定。[结果]在改善疾病疗效方面,三者效果相当(P>0.05);在改善中医证候方面,茸菖胶囊与抗痫胶囊疗效相当,均优于卡马西平(P<0.05);在改善认知功能方面,茸菖胶囊比抗痫胶囊及卡马西平具有突出的优势(P<0.05)。[结论]以益肾填精法为主的茸菖胶囊具有抗痫与益智双重作用,安全有效,从而为小儿癫痫"从肾论治"提供了可靠的临床依据。

Abstract:

[Objective] To evaluate the efficacy and safety of the method of tonifying kidney and essence replenishment in the treatment of pediatric epilepsy tonic-clonic seizure.[Method] In the study,children with Tonic-clonic seizures were randomly divided into three groups.They were treated with Chopped Chang capsule,anti-epilepsy capsule and Carbamazepine respectively for one year.Evaluate the efficacy through observing seizure frequency,duration,EEG Figure,syndrome,cognitive function,liver and kidney function and other security indicators.[Results] In the respect of improving disease curative effect,the three methods have similar effect(P>0.05).Chopped Chang capsule was similar to anti-epilepsy capsule but superior to Carbamazepine in the respect of improving syndrome of TCM(P<0.05).In the respect of improving cognitive function,Chopped Chang capsule was superior to anti-epilepsy capsule and Carbamazepine(P<0.05).[Conclusion] Chopped Chang capsule which based on the method of tonifying kidney and essence replenishment has dual function of anti-epilepsy and increasing the brainpower.It is safe and effective.The study has provided reliable clinical evidence for pediatric epilepsy treatment from the kidney aspect.