| 摘要: |
| [目的]] 通过正交设计筛选胡黄连的提取工艺,优化出最佳工艺参数。[方法]以提取液中胡黄连苷Ⅰ、Ⅱ转移率及出膏率的加和进行综合评价,采用L9(34)正交实验优选最佳提取工艺。[结果]胡黄连最佳提取工艺为原药材最粗粉浸泡24 h,以每分钟1.5 mL的流速渗漉,收集16倍量的渗漉液。[结论]优选的胡黄连提取工艺合理可行,为实际生产提供参考。 |
| 关键词: 胡黄连 正交实验 胡黄连苷Ⅰ 胡黄连苷Ⅱ 渗漉提取 |
| DOI：10.11656/j.issn.1673-9043.2013.03.09 |
| 分类号: |
| 基金项目:国家科技支撑计划基金项目(2007BAI41B06). |
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| Evaluation of extracted art of Rhizoma Picrorhizae based on multiple criteria comprehensively |
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HOU Wen-bin1,2, ZHOU Fu-jun2, SHAN Qi2, LIU Chang-xiao3
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1.Tianjin University of TCM, Tianjin 300193, China;2.Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China;3.Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the extraction process of Rhizoma Picrorhizae by an orthogonal experiment and to determine the best extraction parameters. [Methods] The L9(34) orthogonal test was employed based on a multiple criteria comprehensively evaluating the yields of picroside I, picroside II, and total extracts. [Results] The optimum extraction process was characterized as: soaking the crude rhizome powders for 24 h and percolating them with 1.5 mL/min of the flow rate and 16 folds of extraction volume were collected. [Conclusion] The extraction technique is stable and available.This study provides an experimental basis for the industrial production of Rhizoma Picrorhizae. |
| Key words: Rhizoma Picrorhizae orthogonal test picroside I picroside II percolation |
