痰热清对放射性肺损伤的干预作用及对TGF-β1影响的临床研究

Effect of Tanreqing on radiation-induced lung injury and expression of TGF-β1

关键词:  放射性肺损伤  痰热清  转化生长因子β1

Key words:  radiation-induced lung injury  Tanreqing  TGF-β1

摘要:

[目的] 观察痰热清对放射性肺损伤的干预作用及对转化生长因子β1（TGF-β1）表达水平的影响. [方法] 将70例放疗肺癌患者按随机数字表法随机分为对照组和治疗组. 对照组完成常规放疗；治疗组于放疗同时应用痰热清注射液20 mL加入5%葡萄糖注射液250 mL中静脉滴注，每日1次，直至放疗结束. 两组放射治疗前、后测定血浆TGF-β1，比较两组放射性肺损伤发生情况. [结果] 放射治疗后两组血浆TGF-β1含量比较差异有统计学意义（P<0.05）；两组急性放射性肺炎总发生率比较差异有统计学意义（P<0.05），且未出现明显药物不良反应. [结论] 痰热清能抑制放射治疗后血浆TGF-β1的过度表达，可有效降低放射性肺损伤的发生率，值得在肺癌等胸部肿瘤放射治疗中推广应用.

Abstract:

[Objective] To observe the effect of intervention with Tanreqing on radiation-induced lung injury and the level of expression of the TGF-β1. [Methods] Seventy cases of radiotherapy in patients with lung cancer were randomly divided into the control group and the treatment group. Routine conventional radiotherapy was given in the control group, while in the treatment group except for radiotherapy the patients were also treated with Tanreqing injection, 20 mL adding into 250 mL of the intravenous infusion of 5% glucose injection, once a day with 15~30 d as a course. We compared the incidence of radiation-induced lung injury between two groups by determination of plasma TGF-β1 before and after treatment. [Results] Difference of plasma TGF-β1 content between two groups after treatment was statistically significant (P<0.001); Difference of total incidence of acute radiation pneumonitis and severity of radiation pneumonitis between two groups were also statistically significant (P<0.05) without significant adverse drug reactions. [Conclusion] Tanreqing can inhibit plasma TGF-β1 over-expression after radiation therapy and can effectively reduce the incidence of radiation-induced lung injury. It is worthy of popularization and application in the treatment of lung cancer and other chest radiation oncology.