| 摘要: |
| [目的] 继续对益母草(Leonurus jAponicus Houtt.)的化学成分进行研究,为进一步开发利用该植物资源提供依据。[方法] 采用正相硅胶、反相ODS、SephAdex LH-20等柱色谱及高效液相色谱法等方法进行分离纯化,并通过理化性质及光谱分析鉴定化合物的结构。[结果] 从益母草体积分数为50% 的乙醇提取物中分离鉴定了7个化合物,分别为(E)-4-hydroxy-dodec-2-enedioic Acid(1)、益母草碱(2)、水苏碱(3)、次黄苷(4)、鸟苷(5)、左旋色氨酸(6)、苯丙氨酸(7)。[结论] 1、4、5、7为从益母草种中首次分离得到的化合物。 |
| 关键词: 益母草 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1673-9043.2014.06.12 |
| 分类号: |
| 基金项目:国家自然基金项目(81202995);国家科技重大专项项目-重大新药创制(2011ZX09307-002-01);新世纪优秀人才支持计划资助(NCET-12-1069,NCET-10-0958)。 |
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| Study on chemical constituents of Leonurus japonicus Houtt. Ⅲ |
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DENG Shen, LIU Li-li, CHEN Yue, LI Xiao-xia, WANG Tao, ZHANG Yi
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Key Laboratory of Traditional Chinese Medicinal Chemistry and Ana lytical Chemistry of Tianjin, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the chemical components of the herb Leonurus japonicus Houtt.Ⅲ.[Methods] The chemical components were obtained by chromatographies, such as silica gel, ODS, Sephadex LH-20 and HPLC. They were identified by the chemical and physical methods, especially spectral analysis. [Results] Seven compounds were obtained and identified as (E)-4-hydroxy-dodec-2-enedioic acid (1), leonurine (2), stachydrine (3), hypoxanthine-9-β-D-ribofuranoside (4), guanosine (5), L-tryptophan (6), and phenylalanine (7), respectively.[Conclusion] Compounds 1, 4, 5, and 7 are the obtained species firstly. |
| Key words: Leonurus japonicus Houtt. chemical component structural elucidation |
