| 摘要: |
| [目的] 明确护肝中药"五田保肝液"的用药安全剂量范围,为临床用药安全提供实验依据.[方法] 依据中药、天然药物急性毒性实验研究技术指导原则设计实验,观察小鼠急性毒性反应,并记录其死亡情况,确定急性毒性实验中五田保肝液半数致死量(LD50)或最大给药量.[结果] 半数致死量实验中未测得LD50,最大给药量实验获得小鼠最大给药量折合生药228 g/(kg·d),相当于成人临床用药量的120倍.[结论] 护肝中药"五田保肝液"急性毒性反应低,临床常用药物剂量安全可靠. |
| 关键词: 五田保肝液 急性毒性实验 半数致死量实验 最大给药量实验 |
| DOI：10.11656/j.issn.1673-9043.2015.01.08 |
| 分类号: |
| 基金项目:天津市中医药管理局中医、中西医结合科研专项课题(13112);天津市滨海新区卫生局医药卫生科技项目(2011BHKZ010). |
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| Study on acute toxicity test of Wutian Hepatoprotective Liquid |
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LIU Jian-wei1, BI Ye-dong2, FAN Ying-chang1, JIANG Xi-juan1, GAO Qing1, GUO Mao-juan1, SU Jin-ling1
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin Binhai New Area of Hangu Hospital of Traditional Chinese Medicine, Tianjin 300380, China
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| Abstract: |
| [Objective] Clear safety dose range of Wutian hepatoprotective liquid, to provide the experimental basis for the clinical medication safety.[Methods] On the basis of acute toxicity of natural drug testing technology guidelines for research design, to observe the acute toxicity in mice, and record the death, to determine the acute toxicity test of Wutian Hepatoprotective liquid median lethal dose (LD50) or the maximum dose. [Results] The median lethal LD50 hadn't been measured in the experiment, and the maximum dose of the experimental mice had maximum dose equivalent 228g/(kg·d), equivalent to the adult clinical use of the drug 120 times. [Conclusion] The liver protecting medicine "Wutian Hepatoprotective liquid" has low acute toxicity reaction, commonly used in clinical drug safety. |
| Key words: Wutian Hepatoprotective liquid acute toxicity test median lethal dose test the maximum dose test |
