| 摘要: |
| [目的] 继续研究蜀葵花[Althaea rosea (Linn.) Cavan.]中的化学成分。[方法] 采用硅胶、ODS等柱色谱及高效液相色谱(HPLC)手段对蜀葵花中的二氢黄酮类成分进行分离纯化, 并通过波谱分析方法鉴定单体成分的结构。[结果] 从蜀葵花的95%乙醇提取物中分离鉴定了8个二氢黄酮类成分, 分别为(2R, 3R)-二氢山柰酚-4'-O-β-D-吡喃葡萄糖苷(1)、(2R, 3R)-(+)-花旗松素(2)、(2R, 3R)-花旗松素-3'-O-β-D-吡喃葡萄糖苷(3)、(2R, 3R)-花旗松素-7-O-β-D-吡喃葡萄糖苷(4)、(2R, 3R)-二氢杨梅素-3'-O-葡萄糖苷(5)、(2R, 3R)-3, 5, 6, 7, 4'-pentahydroxyflavanonol(6)、(2S)-4', 5, 7-三羟基黄烷酮(7)、南酸枣苷(8).[结论] 3~6为首次从蜀葵属中分离得到的化合物, 并利用圆二色光谱确定了所有化合物的绝对构型。 |
| 关键词: 蜀葵花 化学成分 二氢黄酮 结构鉴定 绝对构型 |
| DOI：10.11656/j.issn.1673-9043.2015.04.11 |
| 分类号: |
| 基金项目:国家自然基金项目(81202995);新世纪优秀人才支持计划资助(NCET-12-1069);天津市高等学校创新团队培养计划资助项目(TD12-5033)。 |
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| Isolation and structural identification of Flavonones from Althaea rosea flowers |
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CHAO Li-ping, CHEN Qiu, SHI Ping-ping, LI Xiao-xia, WANG Tao, ZHANG Yi
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Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China
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| Abstract: |
| [Objective] Continue to study the constituents of Althaea rosea. [Methods] The chemical constituents were obtained through ODS, Silica gel column chromatorgraphies and PHPLC chromatorgraphy and identified by chemical and kinds of spectral analysis. [Results] Eight flavonones were obtained and determined as (2R,3R)-dihydrokaempferol-4'-O-β-D-glucopyranoside (1), (2R,3R)-(+)-taxifolin (2), (2R,3R)-taxifolin-3'-O-β-D-glucopyranoside (3), (2R,3R)-taxifolin-7-O-β-D-glucopyranoside (4), (2R,3R)-dihydromyricetin-3'-O-glucoside (5), (2R,3R)-3,5,6,7,4'-pentahydroxyflavanonol (6), (2S)-4',5,7-trihydroxy flavanone (7), choerospondin (8), respectively. [Conclusion] Compounds 3-6 are obtained from Althaea genus firstly. On the other hand, the absolute configurations of all isolates are determined by CD spectrum. |
| Key words: Althaea Rosea constituents flavonones structural identification absolute configuration |
