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| 心脑舒通中黄酮类成分研究 |
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栾晓莹, 白洋, 陈颖, 谢燕, 胡利民, 常艳旭, 王晓明, 张鹏
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天津中医药大学, 天津市现代中药重点实验室, 天津市中药化学与分析重点实验室, 天津 300193
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| 摘要: |
| [目的] 研究心脑舒通中黄酮类化学成分。[方法] 采用反相色谱中低压柱色谱,硅胶柱色谱及Agilent 1260制备液相色谱方法进行分离纯化,根据NMR和LC-MS数据进行结构鉴定。[结果] 分离得到6个黄酮类化合物,经鉴定分别是槲皮素(1);异鼠李素(2);槲皮素-3-O-β-D-葡萄糖苷(3);槲皮素-3-O-龙胆二糖苷(4);芦丁(5);山奈酚(6).[结论] 首次分离鉴定了心脑舒通中6个黄酮类化学成分。 |
| 关键词: 心脑舒通 蒺藜 黄酮 化学成分 抗血小板 |
| DOI：10.11656/j.issn.1673-9043.2015.05.09 |
| 分类号: |
| 基金项目:重大新药创制项目资助(2011ZX09201-201);国家自然科学基金青年项目资助(81303183). |
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| Research flavonoids from Xinnao Shutong capsules |
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LUAN Xiao-ying, BAI Yang, CHEN Ying, XIE Yan, HU Li-min, CHANG Yan-xu, WANG Xiao-ming, ZHANG Peng
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Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the flavonoids in Xinnao Shutong capsules.[Methods] The compounds were separated and purified by low-pressure column chromatography in the ODS, silica gel chromatography column and preparative liquid chromatography Agilent 1 260. Their structures were elucidated on the basis of NNR and LC-MS data. [Results] The six flavonoids were identified: Quercetin (1); Isorhamnetin (2); Quercetin-3-O-β-D-glycoside (3); Quercetin-3-O-gentiobioside (4); rutin (5); kaempferol (6). [Conclusion] Separating and identifing six flavonoids chemical compositions from Xinnao Shutong capsules are the first time. |
| Key words: Xinnao Shutong Tribulus terrestris L. flavonoids chemical composition antiplatelet |
