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| 冠心舒通胶囊的抗血小板聚集及抗动脉收缩作用 |
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王卫明1,2, 邢晓雪1,2, 高慧1,2, 王玲燕1,2, 刘敏娜1,2, 樊官伟1,2
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1.天津市现代中药重点实验室, 天津 300193;2.天津中医药大学, 天津 300193
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| 摘要: |
| [目的] 检测冠心舒通胶囊在治疗血栓栓塞性疾病中的疗效。[方法] 对比冠脉舒通胶囊对二磷酸腺苷(ADP)和凝血酶诱导的大鼠血小板最大聚集率、抑制率;对比其对去甲肾上腺素和氯化钾(KCl)诱导的大鼠胸主动脉环收缩的舒张率。[结果] 冠心舒通胶囊对ADP和凝血酶诱导的血小板聚集有抑制作用;对去甲肾上腺素和KCl诱导的大鼠胸主动脉收缩有舒张作用。[结论] 冠心舒通胶囊对血栓栓塞性疾病有确切疗效。 |
| 关键词: 冠心舒通胶囊 血小板 动脉环 |
| DOI：10.11656/j.issn.1673-9043.2016.02.09 |
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| Anti-platelet aggregation and anti-atrial contractile effect of Guanxinshutong capsule |
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WANG Wei-ming1,2, XING Xiao-xue1,2, GAO Hui1,2, WANG Ling-yan1,2, LIU Min-na1,2, FAN Guan-wei1,2
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1.Research Centre of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China
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| Abstract: |
| [Objective] Our explicit objective was to study the function of Guanxinshutong capsule in the treatment of thromboembolic disease. [Methods] We determined the maximal aggregation ratio of Adenosine diphosphate (ADP) and Thrombin-induced platelet aggregation and inhibition rate. We further determined the diastolic ratio and KCl norepinephrine-induced contraction of rat aortic ring. [Results] We found that Guanxinshutong capsule had a potential inhibitory effect on platelet aggregation stimulated by ADP and Thrombin. Furthermore, it was found that Guanxinshutong could inhibit both noradrenaline and KCl-induced contraction of aortic ring and the consequent platelet aggregation. [Conclusion] Guanxinshutong capsule has a definite therapeutic effect against thromboembolic disease. |
| Key words: Guanxinshutong capsule platelet aortic ring |
