| 摘要: |
| DNA甲基化属于表观遗传学范畴，它能在DNA序列不发生改变的情况下参与基因的调控与表达。在大肠癌的发病过程中，伴随着DNA的异常甲基化。抑癌基因和原癌基因的异常甲基化均影响肿瘤的发生发展。现对目前与大肠癌相关的基因甲基化的情况，以及在治疗和预防中的作用进行总结与展望。 |
| 关键词: DNA甲基化 表观遗传学 大肠癌 |
| DOI：10.11656/j.issn.1673-9043.2016.06.01 |
| 分类号: |
| 基金项目:国家自然科学基金课题资助（81273636）；天津市重大科技攻关项目-癌症计划（12ZCDZSY16800）。 |
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| DNA methylation associated with colorectal cancer |
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HE Qian, WANG Miao, MENG Jing-yan
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Tianjin University of Traditional Chese Medicine, Tianjin 300193, China
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| Abstract: |
| DNA methylation belongs to the category of epigenetics,which can involve in the regulation and expression of gene without changing the sequence of DNA.In the pathogenesis of colorectal cancer,accompanied by abnormal DNA methylation.The abnormal methylation of tumor suppressor gene and oncogene both affected the occurrence and development of tumor.This review aimed to summarized and prospect the situation of the current gene methylation associated with colorectal cancer,and its function in the treatment and prevention. |
| Key words: DNA methylation epigenetics colorectal cancer |
