中医药治疗2型糖尿病合并抑郁的系统评价

Chinese medicine treatment of type 2 diabetes and depression evaluation system

关键词:  中医药  2型糖尿病  抑郁  临床疗效  系统评价

Key words:  Chinese medicine  type 2 diabetes  depression  clinical efficacy  systematic review

摘要:

[目的] 系统评价中医药治疗2型糖尿病合并抑郁的临床疗效与安全性。[方法] 计算机检索维普数据库、中国知网、万方数据库、中国生物医学文献数据库、Pubmed、Cochrace Library，纳入中医药治疗2型糖尿病合并抑郁的随机对照试验，检索时限均从建库至2015年12月，对纳入研究的资料进行评价，用RevMan 5.3软件进行分析。[结果] 共纳入符合要求的9篇文献，合计593例患者。Meta分析结果显示，与对照组相比，中医药治疗2型糖尿病合并抑郁在总有效率、用药后汉密尔顿（HAMD）评分变化：糖化血红蛋白（HbA1c）变化水平：不良反应方面具有一定的优势，差异均有统计学意义。[结论] 现有研究文献表明试验组对2型糖尿病合并抑郁在总有效率、HAMD、HbA1c变化方面优于对照组，同时在不良反应发生率方面，低于对照组。

Abstract:

[Objective] To evaluate the safety and efficacy of the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus.[Methods] All randomized controlled trials (RCTs) or quasi-randomized controlled trials from the database established to December 2015,It was searched on the VIP,CNKI,Wan fang,CBM,Pubmed,the Cochrane Liabrary about the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus.And then Revman 5.3 was performed for meta-analyses.[Results] Nine trials including 593 cases were identified.Meta-analysis showed that:Compared with control group,the effective rate in The experimental group was higher than control group.Hamilton (HAMD) score changes:glycated hemoglobin (HbA1c) levels:adverse events were superior than normal group,the differences were statistically significant.[Conclusion] The existing research literature suggests that The effects of the traditional Chinese medicine on depression in patients with type 2 diabetes mellitus are better than Western medicine group,especially in the total efficiency,HAMD,HbA1c,and no severe adverse event was reported.