| 摘要: |
| [目的] 为缓解生态压力，扩大药用菊花的临床适用范围，对祁菊非药用部位叶70%乙醇提取物的化学成分进行研究。[方法] 利用多种色谱法，如正相硅胶、反相ODS、Sephadex LH-20及高效液相色谱等进行分离纯化，并通过理化性质及波谱分析鉴定化合物结构。[结果] 从祁菊叶70%乙醇提取物中分离鉴定了6个单体化合物，分别为茵芋苷（1），菊苣苷（2），苯甲基-6-O-β-D-吡喃葡萄糖苷（3），苄醇-O-[β-D-吡喃葡萄糖-（1→6）]-β-D-吡喃葡萄糖苷（4），icariside D1（5），松柏苷（6）。[结论] 化合物4、5为首次从菊属植物中分离得到。 |
| 关键词: 祁菊叶 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1673-9043.2017.01.14 |
| 分类号: |
| 基金项目:大学生创新创业训练计划（201510063003）。 |
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| Study on the constituents of Chrysanthemum morifolium Ramat. Qiju leaves |
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QU Lu, LIU Yan-xia, LI Jian-liang, BU Shu-yang, WANG Tao, ZHANG Yi
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Tianjin University of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China
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| Abstract: |
| [Objective] To alleviate the ecological pressures and expand clinical application scope of Chrysanthemum genus plants, we study the chemical constituents of Chrysanthemum morifolium Ramat. Qiju leaves.[Methods] The chemical compounds were isolated through kinds of chromatorgraphies such as Sephadex LH-20, ODS, Silica gel and PHPLC chromatorgraphies and identified by chemical and spectral analysis (1H, 13C NMR, 1H 1H COSY, HMQC, HMBC, UV, IR, MS).[Results] Six compounds were obtained and identified as skimmin (1), cichoriin (2), benzyl-O-β-D-glucopyranoside (3), benzyl alcohol-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (4), icariside D1 (5), and coniferin (6).[Conclusion] Compounds 4, 5 were obtained from Chrysanthemum genus firstly. |
| Key words: Chrysanthemum morifolium Ramat. Qiju leaves chemical constituents structural identification |
