| 摘要: |
| 丹参是活血化瘀类常用中药之一，具有活血化瘀、调经、凉血消痈、安神的功效。丹参作为单味药或配伍用药广泛应用于临床。临床以及相关实验研究表明，丹参及其所含有的多种化学成分均有雌激素样作用，可通过调节雌激素受体（ER）、促进细胞凋亡等方式抑制乳腺增生、乳腺癌等妇科疾病的发生发展。 |
| 关键词: 丹参 雌激素样作用 作用机制 |
| DOI：10.11656/j.issn.1673-9043.2017.05.02 |
| 分类号:R285.5 |
| 基金项目:天津中医药大学十二五学科师资基金；国家自然基金重点基金（81630106）。 |
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| Advances in mechanism studies on estrogen-like effect of Salvia miltiorrhiza Bge. |
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GUO Ao-wei, PU Wei-ling, LUO Ying-ying, BAI Ru-yu, SHI Hong, ZHOU Kun, GAO Xiu-mei, SUN Li-kang
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Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China
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| Abstract: |
| Salvia miltiorrhiza Bge. is a kind of classical traditional Chinese medicine for promoting blood-system circulation by promoting the blood-system circulation to remove blood stasis and to regulate the menstruation, and by cooling the blood-system to remove carbuncle and tranquilization. It's showed that the pharmacological effects of Salvia miltiorrhiza Bge., in the related experimental research and clinical application. Salvia miltiorrhiza Bge. and its active ingredients were similar to those of phytoestrogens, which were widely used in therapy of gynecological disease, such as breast cancer and hyperplasia of mammary glands, through regulation of ER, promoting cell apoptosis or other pathway. |
| Key words: Salvia miltiorrhiza Bge. estrogen-like effect mechanism |
