冠心病痰瘀互结病机及生物学基础研究概述

An overview of pathogenesis and biological basis in phlegm and blood stasis of coronary heart disease

关键词:  痰瘀互结  动脉粥样硬化  脂质代谢  炎症介质  多态性

Key words:  intermin-gled phlegm and blood stasis  atherosclerosis  lipid metabolism  inflammation mediators  polymorphism

摘要:

近年来，冠心病痰瘀互结证发病率高且病变程度严重，已逐渐引起人们的重视。通过阅读文献，文章从病因病机、脂代谢、炎症介质、同型半胱氨酸、基因多态性等角度对痰瘀互结证可能的生物学基础进行综述。初步认为，冠心病痰瘀互结证的形成包括阴阳气虚，脾胃运化失司，肝失疏泄，痰浊水饮停滞等病因；动脉粥样硬化是多种因素相互作用的结果，是冠心病形成的病理基础之一，动脉粥样硬化及心肌缺血更易出现痰瘀等病理因素。文章从中西医学两个角度出发，对冠心病痰瘀互结证病机及生物学基础进行概述，为临床辨证提供指导意义。

Abstract:

In recent years, due to the high morbidity and serious lesion of intermin-gled phlegm and blood stasis syndrome of CHD, people are paying more attention to it. By reading the literature, we reviewed the possible biological basis of phlegm stasis syndrome from etiology, pathogenesis, lipid metabolism, inflammatory mediators, homocysteine and gene polymorphism. Preliminary studies determined that the formation of intermin-gled phlegm and blood stasis syndrome including yin and yang deficiency, spleen-stomach transportation-metabolism disability, liver dysfunction, the stagnation of phlegm turbidity and retained fluid. AS is the result of interaction of many factors, and is one of the pathological bases for the formation of CHD, AS and myocardial ischemia are particularly likely to show pathological factors such as phlegm turbidity and congestion. This article will overview the pathogenesis and biological basis of intermin-gled phlegm and blood stasis syndrome from traditional Chinese medicine and western medicine, so as to provide guidance for clinical syndrome differentiation.