丹红注射液对老年慢性阻塞性肺疾病急性加重期患者内皮功能和血凝功能的影响

Effects of Danhong injection on endothelial function and coagulation function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

关键词:  丹红注射液  慢性阻塞性肺疾病  内皮功能  血凝学

Key words:  Danhong injection  chronic obstructive pulmonary disease  endothelial function  blood coagulation

摘要:

[目的]观察早期应用丹红注射液对老年慢性阻塞性肺疾病（COPD）急性加重期患者内皮功能和血凝功能的影响。[方法]236例老年COPD急性加重期患者随机分为对照组（118例）、观察组（118例）。对照组给予西医综合治疗，观察组给予常规西医综合治疗+参附注射液。动态监测内皮细胞功能包括E选择素（sE-selectin）和管性血友病因子（vWF）；血凝学指标包括活化部分凝血活酶时间（APTT）、D-二聚体（D-D）、血小板计数（PLT）和血栓弹力图检测（TEG）；血气分析包括血氧分压（PaO₂）、血氧饱和度（SaO₂）和血二氧化碳分压（PaCO₂）；应用中医证候评分评价病情好转情况。[结果]治疗前，两组sE-selectin、vWF、血凝学指标、血气指标以及证候评分，差异无统计学差异（P>0.05）。治疗后，观察组PaO₂、SaO₂、PaCO₂以及中医证候评分改善情况优于对照组（P<0.05）；观察组sE-selectin、vWF、APTT、D-D、TEG的R值和K值低于对照组，PLT、a角和MA值高于对照组（P<0.05）。[结论]丹红注射液可减轻老年COPD急性加重期患者内皮功能损伤、改善血凝状态，有利于患者的转归。

Abstract:

[Objective] To observe the effect of early application of Danhong injection on elderly patients with chronic obstructive pulmonary disease (COPD) effect in patients with acute exacerbation of endothelial function and blood coagulation function.[Methods] According to the coin method, 236 elderly patients with acute exacerbation of COPD were divided into control group (n=118) and observation group (n=118). The control group was treated with western medicine, while the observation group was treated with routine western medicine combined with Shenfu injection. Dynamic monitoring of endothelial cell function included E selectin (sE-selectin) and von Willebrand factor (vWF) rating; blood coagulation indexes included activated partial thromboplastin time (APTT), D-two poly (D-D), platelet count (PLT) and Thrombelastogram detection (TEG); blood gas analysis included oxygen partial pressure (PaO₂), oxygen saturation (SaO₂) and blood pressure of carbon dioxide (PaCO₂);TCM symptom score was used to evaluate the condition.[Results] Before treatment, there was no significant difference in sE-selectin, vWF, blood coagulation index, blood gas index and symptom score between the two groups (P>0.05). After treatment, the PaO₂, SaO₂, PaCO₂ and TCM symptom score of the observation group were improved better than the control group (P<0.05); the sE-selectin, vWF, APTT, D-D, R and K values of TEG of the observation group were lower than the control group, the PLT, a angle and MA value of the observation group were higher than that of control group (P<0.05).[Conclusion] Danhong injection could reduce the endothelial dysfunction and improve the coagulation state in elderly patients with acute exacerbation of COPD, which was beneficial to the prognosis of patients.