| 摘要: |
| 肺纤维化（PF）是各种间质性肺疾病晚期的共同结局，目前尚没有有效的治疗方法。粉防己碱为汉防己的主要有效成分之一，在矽肺的治疗方面已经显示出良好的抗纤维化作用，且价格低廉、不良反应少。本文通过复习文献，总结了粉防己碱抗纤维化的主要作用机制包括：抑制炎症反应、改善氧化应激、影响细胞凋亡、干预转化生长因子β（TGF-β）的表达；并对近年来粉防己碱治疗特发性PF的临床报道进行介绍，为粉防己碱治疗特发性PF的临床应用提供理论依据。 |
| 关键词: 粉防己碱 组织纤维化 特发性肺纤维化 |
| DOI：10.11656/j.issn.1673-9043.2018.03.21 |
| 分类号:R563 |
| 基金项目:国家自然科学基金资助项目（81600051）。 |
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| Pharmacological research and application progress of tetrandrine in treating idiopathic pulmonary fibrosis |
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SHANG Lu1,2, DONG Yan2, LIU Bin2, WEI Luqing2, DONG Min2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China
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| Abstract: |
| Pulmoary fibrosis is the final outcome for a variety of interstitial lung disease,and there is no effective treatment. Tetrandrine (Tet) is the main alkaloid isolated from the lumpy root of Stephania tetrandra,and has shown good anti-fibrosis effect in the treatment of silicosis, with low price and few side effects. this paper is intended to summarize the main mechanism of tetrandrine anti-fibrosis,including:uppressing inflammatory reaction; improving oxidative stress; affecting cell apoptosis; interventing the expression of TGF-β1. meanwhile, the clinical reports of tetrandrine in the treatment of idiopathic pulmonary fibrosis in recent years were introduced, which provided theoretical basis for clinical application. |
| Key words: tetrandrine tissues fibrosis idiopathic pulmonary fibrosis |
