| 摘要: |
| 近年来，由于补肝肾、益精血的作用及其乌发的作用，何首乌作为临床用药及保健品用药日益增多，由此关于何首乌及含何首乌的成方制剂导致的药物性肝损伤问题的报道也日渐增多，文章主要对何首乌引起药物性肝损伤的毒性成分及其致肝损伤的可能机制进行综述，并对何首乌致药物性肝损伤的深入研究提出看法。 |
| 关键词: 药物性肝损伤 何首乌 固有型药物性肝损伤 特异质型肝损伤 综述 |
| DOI：10.11656/j.issn.1673-9043.2018.05.03 |
| 分类号:R285.1 |
| 基金项目:重大新药创制专项项目资助（2015ZX09501004-003-004）。 |
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| Progress on the liver toxicity mechanism and toxicity of ingredients induced by Polygonum multiflorum Thunb. |
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REN Hongwei1, SHI Jiangwei2, GAO Xiumei1, WANG Yu1
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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| Abstract: |
| Accumulating reports recently show that oral administration of Polygonum multiflorum Thunb.increases the risk of liver injury. This paper will review the liver toxicity mechanism and toxicity of ingredients induced by Polygonum multiflorum Thunb. |
| Key words: Polygonum multiflorum Thunb. liver injury DILI IDILI review |
