清肺通络法对支原体肺炎痰热闭肺证患儿临床疗效及血清IFN-γ水平的影响

Clinical effects and serum IFN-γ levels of treating children mycoplasma pneumoniae pneumonia with Phlegm-Heat Closed Lungs by Qingfei Tongluo Method

关键词:  清肺通络法  痰热闭肺  肺炎支原体肺炎  临床疗效  IFN-γ

Key words:  Qingfei Tongluo method  phlegm-heat closed lungs  mycoplasma pneumoniae pneumonia  clinical study  IFN-γ

摘要:

[目的] 观察清肺通络法治疗小儿肺炎支原体肺炎痰热闭肺证的临床疗效及血清干扰素-γ（IFN-γ）水平的影响。[方法] 收集2016年12月—2017年5月天津市南开医院儿科肺炎支原体肺炎痰热闭肺证的住院患儿69例，随机分为2组，治疗组35例，对照组34例，两组患儿均于常规西医治疗，治疗组患儿在此基础上加服清肺通络法组方7 d，分别对两组患儿总体疗效、住院天数、各症状持续天数及血清细胞因子IFN-γ水平进行比较。[结果] 最终纳入统计60例，其中治疗组30例，对照组30例，治疗组优于对照组，差异有统计学意义（P<0.05）；治疗组患儿住院天数、发热、咳嗽、咳痰、便干、尿黄持续天数与对照组比较均减少，差异具有统计学意义（P<0.05），两组患儿喘促持续时间比较差异无统计学意义（P>0.05）；两组患儿治疗后IFN-γ差异有统计学意义（P<0.05）；两组患儿治疗后组间及组内IFN-γ水平比较差异有统计学意义（P<0.05）。[结论] 清肺通络法能显著提高肺炎支原体肺炎痰热闭肺证患儿的临床疗效，可显著降低血清细胞因子IFN-γ的水平，具有重要的临床价值，值得临床推广。

Abstract:

[Objective] To evaluate the efficacy of Qingfei Tongluo mixture on Mycoplasma Pneumoniae Pneumonia(MPP) with phlegm-Heat closed lungs and the levels of IFN-γ.[Methods] A total of 69 children with MPP were enrolled at department of pediatrics in Tianjin Nankai Hospital from October 2016 to February 2017. These patients were randomly assigned to two groups, treatment group (n=35) and control group (n=34). All patients were treated with intravenous azithromycin treatment during hospitalization. In addition, the patients in treatment group were given Qingfei Tongluo prescription. The overall efficacy, hospitalization days, the duration of symptoms and serum IFN-γ levels were respectively compared between two groups after 7 days.[Results] Sixty cases were finally enrolled including treatment group (n=30) and control group (n=30). The curative rate was 83.33% in the treatment group and was 53.33% in control group, there was significantly difference related to the curative rate between two groups after the treatment (P<0.05). The hospitalization days and continued days of fever, cough, expectoration, dry stool, and urine in treatment group were lower than those of control group, there were also significantly differences between two groups (P<0.05). There was no significant difference between two groups related to wheezing (P>0.05). There was statistically significant difference in IFN-γ between two groups after treatment (P<0.05). There was statistically significant difference related to IFN-γ before and after treatment (P<0.05).[Conclusion] Qingfei Tongluo method can improve the clinical efficacy of patients with mycoplasma pneumonia of phlegm heat and lung closed type, and can reduce the levels of serum IFN-γ, it was worthy of promoting.