| 摘要: |
| [目的]探讨治疗高脂血症常用中药处方规律，总结中医治疗高脂血症的用药特点。[方法]收集中国已上市治疗高脂血症中成药处方，运用SPSS 19.0软件对各处方中药的用药频率、功效分类、四气、五味、归经频次与频率进行统计分析。[结果]中国目前已上市且功能主治有明确治疗高脂血症的中成药品种有222个，涉及中药饮片212种，用药频率排在前10位的中药饮片分别为山楂、何首乌、决明子、丹参、泽泻、大黄、荷叶、三七、葛根、黄芪。在高频药物中补虚药33种，活血化瘀药15种，药性以温性、平性、寒性居多，药味以甘、苦、辛为主，主要归肝、脾经。[结论]目前已上市治疗高脂血症中成药用药以补虚药和活血化瘀药为主，其次为清热药、消食药和利水渗湿药，反映了高脂血症本虚标实、虚实夹杂的病因病机特点和攻补兼施的用药规律，对临床医生治疗高脂血症遣药组方具有一定的参考价值。 |
| 关键词: 高脂血症 四气 五味 归经 用药规律 |
| DOI：10.11656/j.issn.1673-9043.2018.06.15 |
| 分类号:R589.2 |
| 基金项目:国家自然科学基金重点项目（81430095）；国家重大新药创制科技重大专项项目（2012ZX09101212）。 |
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| Analysis on medication rule in herbal prescriptions for hyperlipidemia in Chinese patent drugs |
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MA Haoling, ZHANG Deqin, DING Liqin, CHEN Xinze, WU Mingjiang, WU Xiaolei, QIU Feng
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Traditional Chinese Medicine Research Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the distribution of Chinese medicine commonly used in hyperlipidemia, and summarize the treatment characteristics of traditional Chinese medicine for hyperlipidemia.[Methods] The composition of prescription medicine had been listed. Software of SPSS 19.0 had been applied to calculate the frequency and percentage of each herbs emerging in these Chinese patent drugs and the categories of these Chinese medicines (efficacy, four natures, five flavors and channel tropism) were statistically analyzed.[Results] Our country has now approved 222 Chinese patent drugs which have clearly stated indications for treating hyperlipidemia, including a total of 212 kinds of traditional Chinese medicines, the top 10 administration frequency of which were hawthorn, Polygonum, Cassia, salvia, Alisma, rhubarb, lotus, Panax, kudzu root, and astragalus. Tonify deficiency medicines (33 kinds) and drugs that could activate blood to remove stasis (15 kinds) were the majority in the high-frequency drugs. The warm, mild and cold nature accounted for the main parts in total four natures of these medicines. The main five flavors and channel tropism were sweet, bitter, pungent and liver meridian, spleen meridian respectively.[Conclusion] Chinese patent medicines for hyperlipidemia contained more tonify deficiency medicines and drugs that could activate blood to remove stasis. Others, such as heat-clearing medicines, digestives and clearing damp and promoting diuresis drugs also play important function to guide the evil out. All these reflected the complicated causes and pathogenesis of hyperlipidemia and the rule of supplementation and purgation drugs simultaneously to remedy the disease. The result can provide clinicians a reference for the best prescription in treating hyperlipidemia. |
| Key words: hyperlipidemia four natures five flavors channel tropism regularity of using drugs |
