| 摘要: |
| 当今社会，脑卒中已成为人类主要致死和致残性的疾病。组织型纤溶酶原激活剂（t-PA）疗法是目前最有效的脑卒中治疗方法。然而，t-PA狭窄的治疗时间窗及其在溶栓再灌注治疗后会引起出血转化、再梗死和再灌注损伤等一些复杂的并发症，并不是所有患者都能在t-PA溶栓治疗后得到良好的愈后结果。因此，需要研究新的药物或治疗方法来改善t-PA溶栓疗法。文章对近几年有关优化t-PA溶栓疗效的方法做一综述。 |
| 关键词: 脑卒中 t-PA溶栓 优化方法 |
| DOI：10.11656/j.issn.1673-9043.2019.01.24 |
| 分类号:R743.3 |
| 基金项目:杜仲通过雌激素受体调节Nrf2-ARE信号通路发挥抗皮肤衰老的机制研究项目编号（2017KJ131）。 |
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| Research progress on optimization of t-PA thrombolytic therapy for stroke |
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TANG Weiwei, XIONG Ke, LI Nan, WANG Shuang, YU Yajun, YAN Yiqi, ZHANG Han
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Biology Department of Institute of traditional Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Stroke has become a major cause of death and disability today.Tissue plasminogen activator (t-PA) therapy is currently the most effective treatment for strokeHowever,t-PA narrow treatment time window and its treatment after thrombolytic reperfusion may cause complications such as bleeding transformation,re-infarction,and reperfusion injury,not all patients can get good results after t-PA thrombolytic therapy.Therefore,we need to study new drugs or treatments to improve t-PA thrombolytic therapy.This article will review the methods of optimizing thrombolytic therapy for t-PA in recent years. |
| Key words: Stroke t-PA thrombolysis optimization methods |
