基于结局路径“top-down”策略的中药功效与物质基础研究思路

Research on the efficacy and material basis of traditional Chinese medicine based on the outcome path “top-down” strategy: Taking traditional Chinese medicine for dispelling rheumatism as the research object

关键词:  功效  物质基础  结局路径  组学  中药

Key words:  efficacy  material basis  outcome path  group science  TCM

摘要:

以祛风湿类中药为例，围绕功效评价的进程效应指标和功效产生的始动因素，阐释"中药功效与物质基础科学内涵的内在关联机制"的研究思路。从功效结局路径（POP）3个关键要素——功效分子起始事件（始动因素）、功效关键事件（功效进程拐点）及功效结局出发，建立中药功效与物质基础研究的新方法。推动中药的质量控制及临床应用。

Abstract:

This study takes Chinese herbal medicine of dispelling rheumatism as an example,and explains the research idea of "the internal correlation mechanism between the efficacy of traditional Chinese medicine and the connotation of material basic science" around the process effect index and the starting factor of efficacy evaluation. Based on the three key factors of (Pharmacy Outcome Pathway) POP,the initiation event of efficacy molecule (initiator),the inflexion of efficacy process (inflexion of efficacy process) and the outcome of efficacy,this study took Chinese herbal medicine for dispelling rheumatism as an example. To establish a new method for the study of the efficacy and material base of traditional Chinese medicine. This study will provide a new suitable modularization method for the study of the efficacy and material basis of traditional Chinese medicine for dispelling rheumatism and promoting the quality control and clinical application of traditional Chinese medicine.