| 摘要: |
| 淫羊藿作为补肾阳中药，具有悠久的用药历史。通过回顾淫羊藿化学成分分析及其药代动力学研究，发现淫羊藿成分复杂多样（如黄酮类、生物碱类、酚酸类等），易受到品种、产地、部位、加工炮制等因素的影响，且淫羊藿各类成分的体内过程差异较大，疾病、组方配伍、炮制加工及中西药联用对其药代动力学参数均有不同程度的影响。文章归纳淫羊藿成分分析及体内过程的研究思路和方法，探讨了目前研究中存在的一些问题，以期为淫羊藿质量控制、新药开发与临床应用研究提供参考。 |
| 关键词: 淫羊藿 化学成分 分析方法 药代动力学 研究进展 |
| DOI：10.11656/j.issn.1673-9043.2019.03.04 |
| 分类号:R285.5 |
| 基金项目:国家自然科学基金项目（81673824）；天津市科技计划项目（15YDLJSY00100）。 |
|
| Research progress on the quantitative analysis of chemical constituents in Epimedium herb and its pharmacokinetics |
|
OUYANG Huizi1, HE Jun2,3
|
|
1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;3.Tianjin State Key Laboratory of Modern Chinese Medicine, Co-construction of Province and Ministry, State Key Laboratory Breeding Base, Tianjin 301617, China
|
| Abstract: |
| Epimedium herb, as a traditional herb medicine for tonifying Kidney Yang, had a long history of use in Chinese medicine. Our paper had reviewed the relevant literature of chemical analysis and pharmacokinetics of Epimedium. It was found that Epimedium contained many active constituents (such as flavonoids, alkaloids, phenolic acids and so on), and its active constituents were differently affected by many factors such as cultivars, place of production, medicinal site, and processing. The bioavailability of various components of Epimedium in vivo was different, and the pharmacokinetics was differently affected by many factors such as disease, prescription compatibility, processing, and drug interaction. According to the summary of quantitative analysis of active constituents in Epimedium and the pharmacokinetic properties, some problems existed in the present research had been discussed to provide a reference for the quality control, drug development and clinical application of Epimedium herb. |
| Key words: Epimedium chemical constituents analysis method pharmacokinetics research progress |
