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| 苦参在银屑病中的应用及研究进展 |
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吕宏蓬1,2, 刘欣1,3, 孟旭1, 陈维文1, 鲜馥阳1,2, 季云润1, 李亚帆1,2, 张广中1
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1.首都医科大学附属北京中医医院, 北京 100010;2.北京中医药大学, 北京 100029;3.北京市中医研究所, 北京 100010
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| 摘要: |
| 银屑病病因复杂，中医认为主要由风、湿、热邪等所致。中医药治疗银屑病具有显著优势。苦参具有清热燥湿，解毒抗炎的功效，在中医药治疗银屑病的复方、单味药及其有效成分中应用广泛，并且具有很好临床疗效。文章从苦参治疗银屑病的临床应用、化学成分、有效成分现代药理学作用三个方面进行论述，探讨苦参在银屑病中发挥治疗作用的机制，为苦参临床应用以及药物开发提供新的思路。 |
| 关键词: 苦参 苦参碱 氧化苦参碱 银屑病 研究进展 |
| DOI：10.11656/j.issn.1673-9043.2019.03.22 |
| 分类号:R758.63 |
| 基金项目:国家自然科学基金项目（81673974）；北京市自然科学基金项目（7172097）；北京市中医药科技项目（JJ2016-46）；北京市重点实验室基金项目（BZ0375）；北京市医院管理局"青苗"计划（QML20161003）；北京市医院管理局"培育"计划项目（PZ2017008）。 |
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| Progress of Sophora Flavescens in Psoriasis Treatment |
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LV Hongpeng1,2, LIU Xin1,3, MENG Xu1, CHEN Weiwen1, XIAN Fuyang1,2, JI Yunrun1, LI Yafan1,2, ZHANG Guangzhong1
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1.Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing 100010, China;2.Beijing University of Chinese Medicine, Beijing 100029, China;3.Beijing Institution of Chinese Medicine, Beijing 100010, China
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| Abstract: |
| Psoriasis is complicated in etiology, which is mainly attributed to wind, humidity, heat and evil. Chinese medicine compounds treatment presents a significant advantage. Sophora Flavescens as well as the single herb and its effective components, is widely used in the treatment of psoriasis by traditional Chinese medicine, which has the functions of clearing heat, eliminating dampness, detoxifying and anti-phlogistic. This paper based on the progress of domestic and foreign research, discussed from three aspects:the clinical application of Sophora Flavescens in psoriasis treatment, Sophora Flavescens chemical components and modern pharmacology research and bioinformatics in order to look for the clues of Sophora Flavescens in the treatment of psoriasis and provide new sight for psoriasis clinical treatment of Sophora Flavescens and drug development. |
| Key words: Sophora Flavescens Oxymatrin matrin psoriasis progress |
