| 摘要: |
| 脂代谢紊乱是前列腺癌（PCa）的一个标志性特征。固醇调节元件结合蛋白（SREBPs）是调节细胞脂类代谢的重要转录因子，能够调控脂肪酸和胆固醇合成关键基因的表达。研究表明SREBPs可能是作为治疗前列腺癌的潜在靶点。总结了SREBPs在前列腺癌发生发展中的作用机制，以及靶向SREBPs治疗前列腺癌的研究进展。 |
| 关键词: 前列腺癌 固醇调节元件结合蛋白 脂代谢 中医药 |
| DOI：10.11656/j.issn.1673-9043.2019.06.23 |
| 分类号:R737.25 |
| 基金项目:国家自然科学基金项目（81703828）。 |
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| Research progress of sterol-regulatory element binding proteins in prostate cancer |
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CHEN Luyao, GUO Yaping, ZHANG Zhaiyi, ZHENG Fang, WANG Tao, PENG Yanfei
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Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| The disorder of lipid metabolism has been considered as a characteristic of prostate cancer (PCa). Sterol-regulatory element binding proteins (SREBPs) acted as vital transcription factors, which can regulate the expression of key genes for fatty acid and cholesterol synthesis. Previous reports indicated that SREBPs were potential therapeutic targets in prostate cancer treatment. This review summarizes the regulatory role of SREBPs in PCa progression and the present research advance in prostate cancer treatment by targeting SREBPs. |
| Key words: prostate cancer sterol-regulatory element binding proteins lipid metabolism traditional Chinese medicine |
