葛根和葛根素治疗糖尿病及并发症的研究进展

Research progress on treatment of diabetes mellitus and complications by Puerariaee lobata radix and puerarin

关键词:  葛根  葛根素  糖尿病  糖尿病并发症

Key words:  Puerariae lobata radix  puerarin  diabetes mellitus  diabetes complications

摘要:

葛根为豆科植物野葛Pueraria lobata（Willd.）Ohwi的干燥根，作为传统中药有悠久的应用历史，多种治疗消渴症的古代方剂中含有葛根，因此在治疗糖尿病的应用上早已引起人们的重视，现代药理研究发现葛根可以通过改善胰岛素抵抗、保护胰岛β细胞、促进糖代谢、改善氧化应激等多途径发挥治疗糖尿病的作用，而糖尿病是一种机制复杂的代谢性疾病，仅针对单一疾病的研究不能完全解释疾病过程，需要结合并发症进行系统研究。近年来葛根及其主要异黄酮类化合物葛根素对糖尿病及糖尿病肝病、肾病、视网膜病变、血管功能障碍、心脏病、糖尿病足、骨质疏松、神经病变、生殖系统功能障碍等多种并发症具有良好的治疗作用，但部分研究尚存在局限，且缺乏针对糖尿病及并发症的联合用药研究，有待进一步探索。

Abstract:

Puerariaee lobata radix is the dry root of Puerariaee lobata (Willd.) Ohwi, belongs to leguminous plant. It has a long application history as a traditional Chinese medicine. Many ancient prescriptions for diabetes mellitus contain Puerariaee lobata radix. Therefore, people have paid much attention to the application of Puerariae lobata radix in the treatment of diabetes mellitus. Modern pharmacological studies have found that Puerariae lobata radix played a role in the treatment of diabetes by improving insulin resistance, protecting islet β cells, promoting glucose metabolism and improving oxidative stress. Diabetes mellitus is a metabolic disease with complex mechanism. The study of single disease can not fully explain the course of disease, so it needs to systematically study in combination with complications. In recent years, Puerariae lobata radix and puerarin have good therapeutic effects on diabetes mellitus, diabetic liver disease, nephropathy, retinopathy, vascular dysfunction, heart disease, diabetic foot, osteoporosis, neuropathy, reproductive system dysfunction and other complications. However, some studies have limitations and lacked of combined use of drugs for diabetes and complications. The pharmacological effects of Puerariae lobata radix on diabetic complications need to be further studied.