夏枯草口服液应用于乳腺纤维腺瘤手术后的临床研究

Clinical study on the application of Xiakucao Oral Liquid in fibroadenoma of breast surgery

关键词:  夏枯草口服液  乳腺手术  切口感染

Key words:  Xiakucao Oral Liquid  breast surgery  incision infection

摘要:

[目的] 探讨乳腺纤维腺瘤手术后使用夏枯草口服液与其术后切口感染的关系。[方法] 采用前瞻性随机对照的方法收集202例乳腺纤维腺瘤手术后患者，按随机数表法分为治疗组（101例）和对照组（101例），对照组的患者采用常规治疗，治疗组患者在术后第1天在常规治疗的基础上给予夏枯草口服液治疗，治疗时间为4周。对两组患者的血清反应蛋白（CRP）、白介素-2（IL-2）、白介素-6（IL-6），切口炎性反应及肿胀程度、术后切口渗出量、切口疼痛评分、愈合时间、愈合等级、住院时间及患者满意度进行观察比较。[结果] 治疗组能较快降低血清IL-2、IL-6水平；治疗组在手术切口炎性反应及肿胀程度、切口引流量、切口疼痛评分、切口愈合时间方面均优于对照组，两组差异具有统计学意义（P<0.05）；治疗组甲级愈合数多于对照组，两组差异无统计学差异（P>0.05）。。[结论] 夏枯草口服液应用于乳腺纤维腺瘤手术可有效改善术后机体免疫应激反应，缓解术后切口炎性反应、肿胀程度及切口疼痛，减少术后切口渗液量，减少切口感染的发生，缩短患者切口愈合时间，且无明显不良反应。

Abstract:

[Objective] To explore the relationship between the use of Xiakucao Oral Liquid and the postoperative incision infection. [Methods] The 202 patients with breast fibroadenoma were randomly divided into treatment group (101 cases) and control group (101 cases). Patients in the control group received routine treatment. Patients in the treatment group were treated with Xiakucao Oral Liquid on the first day after the surgery on the basis of routine treatment, and the treatment time was 4 weeks. The serum CRP, IL-2, IL-6, inflammatory reaction and swelling degree of incision, postoperative incision exudation, incision pain score, healing time, healing grade, hospitalization time and patient satisfaction were observed and compared between the two groups. [Results] The level of IL-2 and IL-6 in the treatment group decreased rapidly. The treatment group was superior to the control group in the inflammatory reaction and swelling degree of surgical incision, incision drainage volume, incision pain score and incision healing time. The difference between the two groups was statistically significant(P<0. 05). The number of grade a healing in the treatment group was more than that in the control group, There was no significant difference between the two groups(P>0. 05). [Conclusion] The application of Xiakucao Oral Liquid in fibroadenoma of breast surgery can effectively improve the postoperative stress response, relieve the postoperative incision inflammatory reaction, swelling degree and incision pain, reduce the amount of postoperative incision exudation, reduce the incidence of incision infection, shorten the healing time of patients' incision, and have no obvious adverse reactions.