| 摘要: |
| 二去水卫矛醇（DAG）和二乙酰二去水卫矛醇（DADAG）在抗肿瘤方面有较强的药理作用，对白血病、脑肿瘤、肝癌、肺癌等皆有效，尤其是治疗慢性粒细胞白血病方面效果较好，鉴于其医疗价值，且DAD和DADAG生物活性多样，可以从多个方面实现抗肿瘤的作用，学者们也将其作用于不同类型的肿瘤细胞，以挖掘更大的应用价值。文章通过综述其对肿瘤的作用及机制，希望能够较为全面地揭示出DAG和DADAG可能的应用方向，为其更好地应用于临床提供启示和思路。 |
| 关键词: 二去水卫矛醇 二乙酰二去水卫矛醇 抗肿瘤 |
| DOI：10.11656/j.issn.1673-9043.2021.05.24 |
| 分类号:R730 |
| 基金项目:国家重点研发计划（2016YFC0501007-03）。 |
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| Progress in the study of antitumor effects of 1,2: 5,6-Dianhydrogalactitol and diacetyldianhydrogalactitol |
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SHEN Yajuan1, DENG Nan1, DING Hui1, ZHANG Lijuan1, SONG Xinbo1, YANG Jianhui2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Tianshili Group Co. Ltd., Tianjin 300402, China
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| Abstract: |
| 1, 2:5, 6-Dianhydrogalactitol (DAG) and diacetyldianhydrogalactitol (DADAG) has strong pharmacological effects in antitumor, for leukemia, brain tumor, liver cancer, lung cancer is effective, especially in patients with chronic myelocytic leukemia. In view of its medical value, DAD and DADAG biological activity is diversiform, can achieve antitumor effect from several aspects, scholars have also to be applied to different types of cancer cells, greater application value in mining. By reviewing its effects and mechanisms on cancer, this paper hopes to fully reveal the possible application directions of DAG and DADAG, so as to provide enlightenment and ideas for their better application in clinical practice. |
| Key words: 1,2:5,6-dianhydrogalactitol diacetyldianhydrogalactitol antitumor |
