| 摘要: |
| 淀粉样前体蛋白（APP）代谢异常导致β淀粉样蛋白（β-amyloid peptide Aβ）沉积，此过程与阿尔茨海默病（AD）的发生、发展密切相关。寻找调控APP代谢途径治疗AD的潜在药物是目前该领域的研究热点之一。对近年来中医药调节"APP代谢途径"中不同靶点的研究进展进行综述，探寻中医药治疗AD的作用机制，为防治AD提供新思路及实验依据。 |
| 关键词: 阿尔茨海默病 APP代谢途径 中医药 |
| DOI：10.11656/j.issn.1673-9043.2021.06.25 |
| 分类号:R749.16 |
| 基金项目:天津市自然科学基金项目（19JCQNJC10700）；天津市卫生和计划生育委员会项目（2017135）。 |
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| Advances in research of traditional Chinese medicine regulating “APP metabolic pathway” in the treatment of Alzheimer's disease |
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LIAN Yunzhuo1, ZHANG Linlin2, CHENG Ruzhen1, SUN Weiming2, XU Jiachun2, WANG Kai2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China
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| Abstract: |
| The abnormal metabolism of amyloid precursor protein (APP) leads to the deposition of β-amyloid peptide Aβ,which is closely related to the occurrence and development of Alzheimer's disease (AD). Finding potential drugs involved in the regulation of APP metabolic pathways for the treatment of AD is one of the hotspots in the field of Alzheimer's disease research. In recent years,the research progress of different targets in the regulation of "APP metabolic pathway" by traditional Chinese medicine has been reviewed,and the mechanism of action of traditional Chinese medicine in treating AD has been explored,which provides experimental basis for traditional Chinese medicine to participate in the prevention and treatment of AD. |
| Key words: Alzheimer's disease APP metabolic pathway traditional Chinese medicine |
