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| 胡黄连苷Ⅱ药理作用研究进展 |
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蔡楠1,2, 李晓璇1, 赵利斌1,3, 曹宁宁1, 肖学凤1, 刘昌孝4
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1.天津中医药大学中药学院, 天津 301617;2.天士力控股集团有限公司研究院现代中药开发中心, 天津 300410;3.北京振东光明药物研究院, 北京 100085;4.天津药物研究院释药技术与药物代谢动力学国家重点实验室, 天津 300301
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| 摘要: |
| 中药胡黄连为玄参科植物胡黄连的干燥根茎，具有退虚热、除疳热、清湿热的功效，是常用的清虚热药，主产于四川、云南、西藏等地。现代研究表明胡黄连在治疗肝脏疾病、皮肤病、消化不良等方面具有良好的疗效。胡黄连苷Ⅱ是中药胡黄连的主要有效成分之一，具有抗炎、抗氧化应激、抗细胞凋亡、抗肿瘤和抗纤维化等多种药理作用。文章通过对近年来国内外开展的关于胡黄连苷Ⅱ药理作用的研究进行综述，以期为胡黄连苷Ⅱ的进一步研发与利用提供参考。 |
| 关键词: 胡黄连苷Ⅱ 胡黄连 药理作用 研究进展 |
| DOI：10.11656/j.issn.1673-9043.2022.01.23 |
| 分类号:R285 |
| 基金项目:国家自然科学基金项目（81973557）；天津市自然科学基金重点项目（20JCZDJC00010）；国家科技重大专项项目（2018ZX09737-019，2018ZX09303-024）；天津中医药大学研究生科研创新项目（YJSKC-20201013）。 |
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| Research progress on pharmacological effects of picroside Ⅱ |
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CAI Nan1,2, LI Xiaoxuan1, ZHAO Libin1,3, CAO Ningning1, XIAO Xuefeng1, LIU Changxiao4
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1.School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Traditional Chinese Medicine Research Center, Tasly Holding Group Co. Ltd., Tianjin 300410, China;3.Zhendong Guangming Pharmaceutical Research Institute, Beijing 100085, China;4.State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China
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| Abstract: |
| Rhizoma picrorhizae, the dried rhizome of Picrorhiza scrophulariiflora Pennell, has the effects of dispelling deficiency heat, eliminating chancre fever and clearing heat and dampness. It has been widely used in clearing deficiency and heat. Rhizoma picrorhizae is mainly produced in Sichuan, Yunnan, Tibet and other places. Currently modern studies have shown that Rhizoma picrorhizae plays an important role in treating liver disease, skin disease and dyspepsia. Picroside Ⅱ is one of the main effective components of the traditional Chinese medicine Rhizoma picrorhizae. It has various pharmacological effects, such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, anti-tumor and anti-fibrosis. Related research progress on pharmacological effects of picroside Ⅱ at home and abroad in recent years are reviewed in this paper, which will provide references for the further development of picroside Ⅱ. |
| Key words: picroside Ⅱ Rhizoma picrorhizae pharmacological effects research development |
