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| 活心丸治疗心血管疾病的研究进展 |
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惠稼祺1,2,3,4, 信琪琪1,2, 袁蓉1,2, 缪宇1,2, 徐凤芹2,3, 丛伟红1,2
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1.中国中医科学院西苑医院心血管病实验室, 北京 100091;2.中国中医科学院西苑医院国家中医心血管病临床医学研究中心, 北京 100091;3.中国中医科学院老年医学研究所, 北京 100091;4.中国中医科学院研究生院, 北京 100091
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| 摘要: |
| 心血管疾病属于中医“心系病证”范畴，其患病率、病死率高，造成了巨大的社会负担。中医药对多种心血管疾病具有良好的治疗作用。中药活心丸具有益气活血、温经通脉的功效，被广泛应用于冠心病心绞痛等多种心血管疾病的治疗。近5年的临床及基础研究表明活心丸可通过抗心肌纤维化、抗氧化应激、抗炎和抑制心肌细胞凋亡等多种机制干预心血管病。为明确其应用现状及研究进展，文章从临床及基础研究角度对活心丸的相关研究进行了综述，从活心丸的组方、临床应用及药理作用等层面，对相关文献进行系统梳理和阐述，探讨活心丸在心血管疾病中的应用及研究进展，为其临床应用及进一步开发提供参考。 |
| 关键词: 活心丸 心血管疾病 抗心肌纤维化 抗氧化 抗炎 细胞凋亡 |
| DOI：10.11656/j.issn.1673-9043.2022.03.23 |
| 分类号:R54 |
| 基金项目:中国中医科学院科技创新重大攻关项目（CI2021A00914）；国家中医药管理局中医药传承与创新“百千万”人才工程（岐黄工程）岐黄学者项目（02045006）；2019国家中医药管理局中医药循证能力建设项目（ZZ13-024-4）。 |
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| Advance on study of Huoxin Pills for cardiovascular diseases |
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HUI Jiaqi1,2,3,4, XIN Qiqi1,2, YUAN Rong1,2, MIAO Yu1,2, XU Fengqin2,3, CONG Weihong1,2
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1.Laboratory of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;2.National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, China;3.Institute of Geriatrics of China Academy of Chinese Medical Sciences, Beijing 100091, China;4.Graduate school of China Academy of Chinese Medical Sciences, Beijing 100091, China
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| Abstract: |
| Cardiovascular diseases(CVDs) belong to the category of "heart disease syndrome" in traditional Chinese medicine. The high prevalence and mortality rate of CVDs caused a huge social burden. Traditional Chinese medicine has efficient therapeutic functions on various types of CVDs. Huoxin Pill which plays an important role in enriching qi and activating blood, warming and activating meridian, has been extensively used in CVDs such as angina pectoris. Clinical and basic researches during the past 5 years have shown that Huoxin Pill has a certain role in improving cardiac function and cardioprotective by suppressing myocardial fibrosis, oxidative stress, inflammatory, and inhibiting cardiac apoptosis. To clarify Huoxin Pill's current and potential application, this paper reviews the literature on Huoxin Pill in CVDs from the perspectives of composition, clinical applications, and pharmacological mechanisms to provide theoretical reference for intensive research. |
| Key words: Huoxin Pill cardiovascular diseases anti-myocardial fibrosis anti-oxidative stress anti-inflammatory cardiac apoptosis |
