细菌耐药机制研究进展及新药研发策略

Research progress of bacterial resistance mechanism and new drug development strategy

关键词:  耐甲氧西林金黄色葡萄球菌  鲍曼不动杆菌  中药抗菌  耐药机制  外排泵  生物膜  β-内酰胺酶

Key words:  MRSA  AB  Chinese medicine antibacterial  resistance mechanism  efflux pump  biofilm  β-lactamase

摘要:

进入21世纪以来，由于抗生素的滥用导致了许多耐药细菌的产生，甚至出现了“超级细菌”，导致临床感染及抗生素经验性治疗失败。文章以耐甲氧西林金黄色葡萄球菌（MRSA）和鲍曼不动杆菌（AB）为例，从细菌的耐药现状、趋势及细菌耐药机制3个方面进行阐述，探讨中药治疗细菌性感染疾病的优势，讨论抗菌新药研发新策略，揭示菌株耐药的根本原理，以期找到逆转消除耐药性的方法，为未来细菌防治研究、中药治疗细菌性感染及抗菌新药研发提供新思路。

Abstract:

Since the beginning of the 21st century,the abuse of antibiotics has led to the production of many drug-resistant bacteria,even "super bacteria" have appeared. This situation led to clinical infections and the failure of empirical antibiotic therapy. This paper reviews and discusses the current status,trends and mechanisms of bacterial resistance,which takes Methicillin-resistant staphylococcus aureus and Acinetobacter baumannii as examples. Discuss the advantages of traditional Chinese medicine in the treatment of bacterial infections and the new strategies for the development of new antibacterial drugs. Reveal the fundamental principle of bacterial resistance,in order to find a way to reverse and eliminate resistance,provide new ideas for future research on bacterial prevention,treatment of bacterial infections with traditional Chinese medicine,and development of new antibacterial drugs.