基于糖皮质激素受体信号通路中药抗抑郁作用及机制的研究进展

Advances in the antidepressant effects and mechanisms of traditional Chinese medicine based on glucocorticoid receptor signaling pathway

关键词:  抑郁症  中药  糖皮质激素  糖皮质激素受体  机制

Key words:  depression  Chinese medicine  glucocorticoid  glucocorticoid receptor  mechanism

摘要:

抑郁症发病机制复杂，其典型病理特征是糖皮质激素（GC）水平的异常升高和下丘脑-垂体-肾上腺（HPA）轴功能亢进，主要由GC受体（GR）介导。研究表明，由抑郁症患者GR功能降低和数量减少引起的HPA轴功能亢进是抑郁症的诱因之一。而抗抑郁药可以改善GR的异常变化，提示GR是抗抑郁的一个新靶点。近年来，中药在治疗抑郁症方面取得了很大进展，文章就中药基于GR途径治疗抑郁症的作用及机制进行综述，以期为临床治疗抑郁症提供参考。

Abstract:

The pathogenesis of depression is complex. The depression is typically characterised by abnormally high glucocorticoid (GC) levels and hyperfunction of the hypothalamic-pituitary-adrenal (HPA) axis,which is mainly mediated by the glucocorticoid receptor (GR). This is mainly mediated by the GR. Studies have shown that hyperfunction of the HPA axis,caused by reduced GR function and decreased numbers in depressed patients,is one of the triggers of depression. And antidepressants can improve the abnormal changes in GR,suggesting that GR is a new target for antidepressants. In recent years,Chinese medicine has made great progress in the treatment of depression. This paper reviews the role and mechanism of Chinese medicine based on GR pathway in the treatment of depression,so that it can provide a reference for clinical treatment of depression.