基于Meta分析的稳心颗粒治疗室性早搏的疗效评价

Evaluation of the efficacy Wenxin Granule in the treatment of ventricular premature beats based on Meta-analysis

关键词:  稳心颗粒  Meta分析  经济学评价  临床疗效

Key words:  Wenxin Granule  Meta analysis  economic evaluation  clinical efficacy

摘要:

[目的] 评价稳心颗粒治疗室性早搏的有效性、安全性和经济性。[方法] 以“稳心颗粒”“稳心”“Wenxin granule”“Wenxin”等为检索词，计算机检索中国知网（CNKI）、万方数据库（W.F）、维普数据库（VIP）、Pubmed及The Cochrane Library等数据库（2000年1月—2020年8月），并手工检索相关期刊与会议论文，筛选稳心颗粒治疗室性早搏的随机对照试验文献。使用RevMan5.3软件进行Meta分析，结合成本—效果进行经济学评价。[结果] 纳入10篇文献，共995例患者。Meta分析结果显示；与心律平相比，稳心颗粒治疗室性早搏提高了临床疗效、改善了动态心电图与心电图疗效；降低了不良反应发生率。药物经济学显示，稳心颗粒治疗室性早搏具有成本效果优势。单因素敏感度分析证实了结果的稳定性。[结论] 稳心颗粒治疗室性早搏有较好的有效性、安全性和经济性，但还需要大量高质量的样本进行随机对照试验，并加以验证。

Abstract:

[Objective] Based on Meta-analysis of the effectiveness, safety, and economy of Wenxin Granules in the treatment of ventricular premature beats.[Methods] Using "Wenxin granule" "Wenxin" as search terms, a computer search of China Knowledge Network (CNKI), Wanfang database (WF), VIP database (VIP), Pubmed and The Cochrane Library and other databases (January 2000 to August 2020), and manually search-related journals and conference papers to screen randomized controlled trials literature of Wenxin granules in the treatment of ventricular premature beats. Use RevMan 5.3 software to carry out Meta-analysis, and carry out an economic evaluation in combination with cost-effectiveness.[Results] The 10 articles were included, with a total of 995 patients. Meta-analysis results show that compared with Xinlvping, Wenxin Granules treatment of ventricular premature beats improves the clinical efficacy, improves the efficacy of dynamic electrocardiogram and electrocardiogram, and reduces the incidence of adverse reactions. Pharmacoeconomics shows that Wenxin Granules have cost-effective advantages in treating ventricular premature beats. Single-factor sensitivity analysis confirmed the stability of the results.[Conclusion] Wenxin Granules has good efficacy, safety, and economy in the treatment of ventricular premature beats, but a large number of high-quality samples are required for randomized controlled trials and verification.