中医药调节失眠伴焦虑神经递质分泌的研究进展

Research progress on regulation of insomnia with anxiety neurotransmitter secretion by traditional Chinese medicine

关键词:  中医药  失眠伴焦虑  神经递质  作用机制

Key words:  traditional Chinese medicine  insomnia with anxiety  neurotransmitter  mechanism of action

摘要:

失眠作为备受关注的公共卫生问题,严重影响个人工作与生活。随着对该疾病的不断认识,发现神经递质在失眠伴焦虑的发病和治疗中有重要调节作用。因此,调控相关机制影响神经递质分泌,使早期截断失眠伴焦虑病情发展具有可能性。运用中医药方法治疗失眠伴焦虑在临床被广泛应用,本文从分子生物学及细胞生物学角度出发,阐述中医药治疗失眠伴焦虑的作用机制。当前研究认为中医药可以通过调控机体免疫应答、肠道菌群、miRNA、细胞间信号通路等多条途径调节神经递质分泌,现就中医药调节失眠伴焦虑中神经递质分泌的作用机制做一综述,以期为中医药治疗失眠伴焦虑提供新的研究思路。

Abstract:

Insomnia,as a public health problem,has attracted much attention and has seriously affected individuals' work and life. With the continuous understanding of the disease,neurotransmitters have been found to have an important regulatory role in the pathogenesis and treatment of insomnia with anxiety. Therefore,the regulation of related mechanisms affects the secretion of neurotransmitters,making it possible to truncate the progression of insomnia with anxiety in the early stage. The treatment of insomnia with anxiety by traditional Chinese medicine(TCM) has been widely used in clinical practice. From the perspective of molecular biology and cell biology,this paper expounds the mechanism of TCM in the treatment of insomnia with anxiety. Current research suggests that TCM can regulate the secretion of neurotransmitters by regulating the body's immune response,intestinal flora,miRNA,intercellular signaling pathways and other pathways. This paper reviews the mechanism of TCM in the regulation of neurotransmitter secretion in insomnia with anxiety,to provide new research ideas for the treatment of insomnia with anxiety by TCM.